Publikationsdatum:
2011-07-23
Beschreibung:
The mechanism that drives the regular beating of individual cilia and flagella, as well as dense ciliary fields, remains unclear. We describe a minimal model system, composed of microtubules and molecular motors, which self-assemble into active bundles exhibiting beating patterns reminiscent of those found in eukaryotic cilia and flagella. These observations suggest that hundreds of molecular motors, acting within an elastic microtubule bundle, spontaneously synchronize their activity to generate large-scale oscillations. Furthermore, we also demonstrate that densely packed, actively bending bundles spontaneously synchronize their beating patterns to produce collective behavior similar to metachronal waves observed in ciliary fields. The simple in vitro system described here could provide insights into beating of isolated eukaryotic cilia and flagella, as well as their synchronization in dense ciliary fields.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172966/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3172966/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sanchez, Timothy -- Welch, David -- Nicastro, Daniela -- Dogic, Zvonimir -- 5K25GM85613/GM/NIGMS NIH HHS/ -- 5R01GM083122/GM/NIGMS NIH HHS/ -- K25 GM085613/GM/NIGMS NIH HHS/ -- K25 GM085613-01/GM/NIGMS NIH HHS/ -- K25 GM085613-02/GM/NIGMS NIH HHS/ -- K25 GM085613-03/GM/NIGMS NIH HHS/ -- K25 GM085613-04/GM/NIGMS NIH HHS/ -- K25 GM085613-05/GM/NIGMS NIH HHS/ -- R01 GM083122/GM/NIGMS NIH HHS/ -- R01 GM083122-01/GM/NIGMS NIH HHS/ -- R01 GM083122-02/GM/NIGMS NIH HHS/ -- R01 GM083122-03/GM/NIGMS NIH HHS/ -- R01 GM083122-03S1/GM/NIGMS NIH HHS/ -- R01 GM083122-03S2/GM/NIGMS NIH HHS/ -- R01 GM083122-04/GM/NIGMS NIH HHS/ -- T32 GM007596/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2011 Jul 22;333(6041):456-9. doi: 10.1126/science.1203963.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physics, Brandeis University, 415 South Street, Waltham, MA 02454, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21778400" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Axoneme/physiology
;
Cilia/chemistry/*physiology
;
Flagella/chemistry/physiology
;
Kinesin/*metabolism
;
Microtubules/chemistry/*physiology/ultrastructure
;
Models, Biological
;
Molecular Motor Proteins/*metabolism
;
Movement
;
Polyethylene Glycols
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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