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  • 1
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    A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in rats (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-09
    Description: Many human diseases are associated with the overproduction of oxygen free radicals that inflict cell damage. A manganese(II) complex with a bis(cyclohexylpyridine)-substituted macrocyclic ligand (M40403) was designed to be a functional mimic of the superoxide dismutase (SOD) enzymes that normally remove these radicals. M40403 had high catalytic SOD activity and was chemically and biologically stable in vivo. Injection of M40403 into rat models of inflammation and ischemia-reperfusion injury protected the animals against tissue damage. Such mimics may result in better clinical therapies for diseases mediated by superoxide radicals.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Salvemini, D -- Wang, Z Q -- Zweier, J L -- Samouilov, A -- Macarthur, H -- Misko, T P -- Currie, M G -- Cuzzocrea, S -- Sikorski, J A -- Riley, D P -- New York, N.Y. -- Science. 1999 Oct 8;286(5438):304-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉MetaPhore Pharmaceuticals, 1910 Innerbelt Business Center Drive, St. Louis, MO 63114, USA. dsalvemini@metaphore.com〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10514375" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Anti-Inflammatory Agents, Non-Steroidal/chemical ; synthesis/chemistry/metabolism/*therapeutic use ; Cytoprotection ; Dinoprostone/metabolism ; Dose-Response Relationship, Drug ; Drug Design ; Drug Stability ; Inflammation/*drug therapy ; Interleukin-1/metabolism ; L-Lactate Dehydrogenase/metabolism ; Male ; Manganese ; Molecular Mimicry ; Neutrophils/drug effects ; Organometallic Compounds/chemical synthesis/chemistry/metabolism/*toxicity ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/*drug therapy ; Splanchnic Circulation ; *Superoxide Dismutase/metabolism ; Superoxides/*metabolism ; Time Factors ; Tumor Necrosis Factor-alpha/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Novel five-coordinate iron(III) complexes produced by oxidation of square-planar (S = 1) iron(II) complexes (1984)
    s.l. : American Chemical Society
    Inorganic chemistry 23 (1984), S. 3235-3241 
    Details
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/ic00188a040
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Density and Expansivity of Solid Argon (1956)
    [s.l.] : Nature Publishing Group
    Nature 178 (1956), S. 483-483 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] For various reasons, argon is the most suitable substance for such a study; but until recently only one of the three coefficients, Cp, has been known accurately for the solid8. Last year, Stewart4 determined the isothermal compressibility (XT) at 65 and 77 K. and Barker and Dobbs5, in this ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/178483a0
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  • 4
    Electronic Resource
    Electronic Resource
    X-Ray Scattering Evidence Regarding the Protein–Nucleic Acid Combination in Nucleoproteins (1953)
    [s.l.] : Nature Publishing Group
    Nature 172 (1953), S. 294-295 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] VARIOUS hypotheses have been advanced concerning the way in which the nucleoprotein complex is built up from its two components, nucleic acid and protein (histone or protamine). On one hand, it has been suggested that the combination of the two constituents is intimate and that the protein ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/172294a0
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  • 5
    Electronic Resource
    Electronic Resource
    Intra-Helix S—S Linked Structures for Insulin (1953)
    [s.l.] : Nature Publishing Group
    Nature 172 (1953), S. 245-246 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WE have briefly mentioned elsewhere1 that we have considered some feasible structures for the insulin molecule by combining the amino-acid sequences of Sanger and his co-workers2 with the a-helix hypothesis of Pauling, Corey and Branson3 and arrived at a limited number of solutions. As this work ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/172245a0
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  • 6
    Electronic Resource
    Electronic Resource
    Structure of Air-Dry Sodium Thymonucleate (1953)
    [s.l.] : Nature Publishing Group
    Nature 172 (1953), S. 803-804 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RECENT stereo-chemical considerations1'2 and X-ray investigations3'4 on the structure of deoxyribose nucleic acids have established with a fair amount of certainty that the structure of the poly-nucleotide chain is a helical one, with the phosphate groups lying on the outside of the helix and the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/172803a0
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  • 7
    Electronic Resource
    Electronic Resource
    Crystal Structure of a Low Molecular Weight Protein: Structure of Dry β-Lactoglobulin Crystals (1951)
    [s.l.] : Nature Publishing Group
    Nature 168 (1951), S. 242-243 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] I AM encouraged by Dr. Dawson's most interesting communication to present some crystallographic results on {J-lactoglobulin which have hitherto only been available in a thesis1 or in articles2 mainly of a review character. Attention will be confined to the dry orthorhombic crystals, often described ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/168242a0
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  • 8
    Electronic Resource
    Electronic Resource
    New Type of X-Ray Evidence on the Molecular Structure of Globular Proteins (1952)
    [s.l.] : Nature Publishing Group
    Nature 169 (1952), S. 138-139 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] THE striking successes of the methods of X-ray diffraction analysis as applied to single crystals composed of relatively small molecules have tended to turn attention away from the usefulness of less detailed analyses in the case of substances of high molecular weight and considerable complexity. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/169138a0
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  • 9
    Electronic Resource
    Electronic Resource
    Structure of the Crystals of Tomato Bushy Stunt Virus Preparations (1938)
    [s.l.] : Nature Publishing Group
    Nature 142 (1938), S. 1075-1075 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WE have examined by X-ray methods crystals of the protein material prepared by F. C. Bawden and N. W. Pirie1 from tomato plants suffering from bushy stunt disease. The crystals were in the form of isotropic rhombic dodecahedra of average diameter of only 0.01 mm. Consequently, no ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1421075a0
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  • 10
    Electronic Resource
    Electronic Resource
    A Derived Patterson Analysis of the Skeleton of the Cyclol C 2 Molecule (1939)
    [s.l.] : Nature Publishing Group
    Nature 143 (1939), S. 648-649 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RECENT publications by Wrinch1, and in particular by Wrinch and Langmuir2, have suggested that the Patterson analyses obtained by Crowfoot3 for air-dried insulin crystals can be interpreted with some precision if one assumes that the basis of the structure of the insulin molecule is the skeleton of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/143648a0
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