Publication Date:
2013-03-23
Description:
The typical pattern of morphological evolution associated with the radiation of a group of related species is the emergence of a novel trait and its subsequent diversification. Yet the genetic mechanisms associated with these two evolutionary steps are poorly characterized. Here, we show that a spot of dark pigment on fly wings emerged from the assembly of a novel gene regulatory module in which a set of pigmentation genes evolved to respond to a common transcriptional regulator determining their spatial distribution. The primitive wing spot pattern subsequently diversified through changes in the expression pattern of this regulator. These results suggest that the genetic changes underlying the emergence and diversification of wing pigmentation patterns are partitioned within genetic networks.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Arnoult, Laurent -- Su, Kathy F Y -- Manoel, Diogo -- Minervino, Caroline -- Magrina, Justine -- Gompel, Nicolas -- Prud'homme, Benjamin -- New York, N.Y. -- Science. 2013 Mar 22;339(6126):1423-6. doi: 10.1126/science.1233749.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Aix-Marseille Universite, CNRS, UMR 7288, Institut de Biologie du Developpement de Marseille-Luminy, 13288 Marseille cedex 9, France.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23520110" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Binding Sites
;
Biological Evolution
;
Drosophila/anatomy & histology/genetics/growth & development
;
Drosophila Proteins/genetics/metabolism
;
Drosophila melanogaster/anatomy & histology/*genetics/growth &
;
development/metabolism
;
*Evolution, Molecular
;
Gene Expression Profiling
;
Gene Expression Regulation, Developmental
;
*Gene Regulatory Networks
;
*Genes, Insect
;
Homeodomain Proteins/genetics/*metabolism
;
Phylogeny
;
Pigmentation/*genetics
;
Pigments, Biological/analysis/metabolism
;
Pupa
;
RNA Interference
;
Transcription Factors/genetics/*metabolism
;
Wings, Animal/*anatomy & histology/chemistry
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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