Publication Date:
1978-09-29
Description:
Owl monkeys were inoculated intracerebrally, subcutaneously, and intravenously with JC, BK, or SV40 virus. Two of four adult owl monkeys inoculated with JC virus, a human polyomavirus, developed brain tumors at 16 and 25 months after inoculation, respectively. A grade 3 to grade 4 astrocytoma (resembling a human glioblastoma multiforme) was found in the left cerebral hemisphere and brainstem of one monkey. The second monkey developed a malignant tumor in the left cerebral hemisphere containing both glial and neuronal cell types. Impression smears prepared from unfixed tissue of this tumor showed cells that contained polyomavirus T antigen. Virion antigens were not detected. Tumor cells cultured in vitro also contained T antigen but were negative for virion antigen. Infectious virus was not isolated from extracts of this tumor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉London, W T -- Houff, S A -- Madden, D L -- Fuccillo, D A -- Gravell, M -- Wallen, W C -- Palmer, A E -- Sever, J L -- Padgett, B L -- Walker, D L -- ZuRhein, G M -- Ohashi, T -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1246-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/211583" target="_blank"〉PubMed〈/a〉
Keywords:
Antibodies, Viral/analysis
;
Antigens, Viral/analysis
;
Brain Neoplasms/*etiology/pathology
;
Immunosuppression
;
Neoplasms, Experimental/etiology/pathology
;
*Polyomavirus/immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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