Publication Date:
2018-03-20
Description:
Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells Wnt ligands influence tumour initiation by controlling the number of intestinal stem cells, Published online: 19 March 2018; doi:10.1038/s41467-018-03426-2 Wnt ligands are essential for intestinal homoeostasis and stem cell maintenance. Here, the authors show that reduction in Wnt secretion reduces the number of intestinal stem cells; this results in rapid fixation of mutated stem cells and accelerated adenoma formation due to lack of cell competition.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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