Publication Date:
2010-01-23
Description:
Wnt/beta-catenin signaling is important in stem cell biology, embryonic development, and disease, including cancer. However, the mechanism of Wnt signal transmission, notably how the receptors are activated, remains incompletely understood. We found that the prorenin receptor (PRR) is a component of the Wnt receptor complex. PRR functions in a renin-independent manner as an adaptor between Wnt receptors and the vacuolar H+-adenosine triphosphatase (V-ATPase) complex. Moreover, PRR and V-ATPase were required to mediate Wnt signaling during antero-posterior patterning of Xenopus early central nervous system development. The results reveal an unsuspected role for the prorenin receptor, V-ATPase activity, and acidification during Wnt/beta-catenin signaling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cruciat, Cristina-Maria -- Ohkawara, Bisei -- Acebron, Sergio P -- Karaulanov, Emil -- Reinhard, Carmen -- Ingelfinger, Dierk -- Boutros, Michael -- Niehrs, Christof -- New York, N.Y. -- Science. 2010 Jan 22;327(5964):459-63. doi: 10.1126/science.1179802.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Embryology, DKFZ-ZMBH Alliance, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20093472" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Body Patterning
;
Cell Line
;
Cell Line, Tumor
;
Central Nervous System/cytology/embryology
;
Embryo, Nonmammalian/metabolism
;
Frizzled Receptors/metabolism
;
Gene Expression Regulation, Developmental
;
Homeodomain Proteins/genetics/metabolism
;
Humans
;
Hydrogen-Ion Concentration
;
LDL-Receptor Related Proteins/metabolism
;
Low Density Lipoprotein Receptor-Related Protein-6
;
Mice
;
Nerve Tissue Proteins/genetics/metabolism
;
Phosphorylation
;
RNA, Small Interfering
;
Receptors, Cell Surface/genetics/*metabolism
;
*Signal Transduction
;
Vacuolar Proton-Translocating ATPases/antagonists & inhibitors/*metabolism
;
Wnt Proteins/*metabolism
;
Wnt3 Protein
;
Xenopus/embryology/metabolism
;
Xenopus Proteins/genetics/*metabolism
;
beta Catenin/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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