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  • 1
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    A mechanosensitive transcriptional mechanism that controls angiogenesis (2009)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2009-02-27
    Description: Angiogenesis is controlled by physical interactions between cells and extracellular matrix as well as soluble angiogenic factors, such as VEGF. However, the mechanism by which mechanical signals integrate with other microenvironmental cues to regulate neovascularization remains unknown. Here we show that the Rho inhibitor, p190RhoGAP (also known as GRLF1), controls capillary network formation in vitro in human microvascular endothelial cells and retinal angiogenesis in vivo by modulating the balance of activities between two antagonistic transcription factors, TFII-I (also known as GTF2I) and GATA2, that govern gene expression of the VEGF receptor VEGFR2 (also known as KDR). Moreover, this new angiogenesis signalling pathway is sensitive to extracellular matrix elasticity as well as soluble VEGF. This is, to our knowledge, the first known functional cross-antagonism between transcription factors that controls tissue morphogenesis, and that responds to both mechanical and chemical cues.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708674/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708674/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mammoto, Akiko -- Connor, Kip M -- Mammoto, Tadanori -- Yung, Chong Wing -- Huh, Dongeun -- Aderman, Christopher M -- Mostoslavsky, Gustavo -- Smith, Lois E H -- Ingber, Donald E -- P01 CA045548/CA/NCI NIH HHS/ -- P01 CA045548-22/CA/NCI NIH HHS/ -- England -- Nature. 2009 Feb 26;457(7233):1103-8. doi: 10.1038/nature07765.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Vascular Biology Program, Department of Pathology & Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19242469" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Animals, Newborn ; Cell Line ; Endothelial Cells/metabolism ; Endothelium, Vascular/cytology/growth & development ; Extracellular Matrix/metabolism ; GATA2 Transcription Factor/metabolism ; Gene Knockdown Techniques ; Guanine Nucleotide Exchange Factors/deficiency/genetics/metabolism ; Humans ; Mice ; Mice, Inbred C57BL ; Neovascularization, Physiologic/*genetics/physiology ; Repressor Proteins/genetics/metabolism ; Retinal Vessels/growth & development/metabolism ; Signal Transduction ; Transcription Factors/deficiency/genetics/*metabolism ; Transcription Factors, TFII/metabolism ; *Transcription, Genetic ; Up-Regulation ; Vascular Endothelial Growth Factor A/metabolism ; Vascular Endothelial Growth Factor Receptor-2/biosynthesis/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 2
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    Reconstituting organ-level lung functions on a chip (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-06-26
    Description: Here, we describe a biomimetic microsystem that reconstitutes the critical functional alveolar-capillary interface of the human lung. This bioinspired microdevice reproduces complex integrated organ-level responses to bacteria and inflammatory cytokines introduced into the alveolar space. In nanotoxicology studies, this lung mimic revealed that cyclic mechanical strain accentuates toxic and inflammatory responses of the lung to silica nanoparticles. Mechanical strain also enhances epithelial and endothelial uptake of nanoparticulates and stimulates their transport into the underlying microvascular channel. Similar effects of physiological breathing on nanoparticle absorption are observed in whole mouse lung. Mechanically active "organ-on-a-chip" microdevices that reconstitute tissue-tissue interfaces critical to organ function may therefore expand the capabilities of cell culture models and provide low-cost alternatives to animal and clinical studies for drug screening and toxicology applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Huh, Dongeun -- Matthews, Benjamin D -- Mammoto, Akiko -- Montoya-Zavala, Martin -- Hsin, Hong Yuan -- Ingber, Donald E -- R01-ES016665/ES/NIEHS NIH HHS/ -- New York, N.Y. -- Science. 2010 Jun 25;328(5986):1662-8. doi: 10.1126/science.1188302.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Wyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20576885" target="_blank"〉PubMed〈/a〉
    Keywords: Air ; Animals ; *Biomimetic Materials ; Blood-Air Barrier ; Capillaries/*physiology ; Capillary Permeability ; Cells, Cultured ; Endothelial Cells/*physiology ; Escherichia coli/immunology ; Humans ; Immunity, Innate ; Inflammation ; Lung/blood supply/physiology ; Mice ; *Microfluidic Analytical Techniques ; Microtechnology ; Nanoparticles/toxicity ; Neutrophil Infiltration ; Oxidative Stress ; Pneumocytes/*physiology ; Pulmonary Alveoli/*blood supply/cytology/immunology/*physiology ; Respiration ; Silicon Dioxide/toxicity ; Stress, Mechanical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Accurate concentration control of mitochondria and nucleoids (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-01-09
    Description: All cellular materials are partitioned between daughters at cell division, but by various mechanisms and with different accuracy. In the yeast Schizosaccharomyces pombe, the mitochondria are pushed to the cell poles by the spindle. We found that mitochondria spatially reequilibrate just before division, and that the mitochondrial volume and DNA-containing nucleoids instead segregate in proportion to the cytoplasm inherited by each daughter. However, nucleoid partitioning errors are suppressed by control at two levels: Mitochondrial volume is actively distributed throughout a cell, and nucleoids are spaced out in semiregular arrays within mitochondria. During the cell cycle, both mitochondria and nucleoids appear to be produced without feedback, creating a net control of fluctuations that is just accurate enough to avoid substantial growth defects.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jajoo, Rishi -- Jung, Yoonseok -- Huh, Dann -- Viana, Matheus P -- Rafelski, Susanne M -- Springer, Michael -- Paulsson, Johan -- GM080177/GM/NIGMS NIH HHS/ -- GM095784/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2016 Jan 8;351(6269):169-72. doi: 10.1126/science.aaa8714.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. ; Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA. ; Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA. johan_paulsson@harvard.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26744405" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Cycle ; Cell Nucleus Division/*physiology ; Cytoplasm/physiology/ultrastructure ; Mitochondria/*physiology/ultrastructure ; Mitochondrial Size ; Protein Kinases/genetics/physiology ; Schizosaccharomyces/cytology/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    Stress-Softening in Crosslinked Block Copolymer Elastomers (1968)
    s.l. : American Chemical Society
    Industrial and engineering chemistry 7 (1968), S. 248-251 
    Details
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/i360028a005
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  • 5
    Electronic Resource
    Electronic Resource
    Spectrometric and thin-layer chromatographic quantification of sulfathiazole residues in honey
    Amsterdam : Elsevier
    Journal of Chromatography A 463 (1989), S. 229-233 
    Details
    ISSN: 0021-9673
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0021-9673(01)84477-0
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  • 6
    Electronic Resource
    Electronic Resource
    Rheo-optical studies of polyurethane block polymers (1972)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-2: Polymer Physics 10 (1972), S. 1521-1527 
    Details
    ISSN: 0449-2978
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Stress and birefringence relaxation have been measured for two polyurethane block polymers at several temperatures to 140°C. Superposition of the stress curves is possible, but the existence of multiple relaxation mechanisms makes such a process of questionable validity. Simple superposition of the birefringence relaxation was not possible. The time and temperature dependence of the stress-optical coefficient implies different mechanisms for mechanical and optical relaxation process. Analysis of the birefringence data requires consideration of nonorientational sources of birefringence.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1972.160100809
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  • 7
    Electronic Resource
    Electronic Resource
    Mechanical and optical properties of block polymers I. Polyester-urethanes (1969)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 9 (1969), S. 383-387 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The extraordinary physical properties exhibited by block polymers have been ascribed to the presence of a multiphase microstructure in which the higher modulus phase acts as a quasi-crosslink or filler particle. Recently, the optical examination of these materials combined with mechanical testing has given investigatiors new insight into this complex morphology. In this investigation, simultaneous stress, strain, and birefringence data have been collected on a block polyester urethane elastomer. Stress-softening is observed in cyclic stress-strain experiments, giving rise to significant hysteresis in the stressstrain and birefringence-stress curves. In these tests, prestrain causes a large increase in the stress-optical coefficient, but has little effect on the strain-optical coeffcient. As the temperature is increased, the strain-optical coefficent decreases while the stress-optical coefficient increases with the latter exhibiting a larger temperature dependence than predicted by the kinetic theory of rubber elasticity. The good agreement between the mechanical-optical response of polyester urethanes and that of other block polymer systems provides further evidence of their morphological similarity.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760090602
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  • 8
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    Memory traces in dynamical systems (2008)
    National Academy of Sciences
    Details
    Publication Date: 2008-11-19
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Sequestering carbon dioxide into complex structures of naturally occurring gas hydrates (2006)
    National Academy of Sciences
    Details
    Publication Date: 2006-08-14
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Conservation law for self-paced movements [Engineering] (2016)
    National Academy of Sciences
    Details
    Publication Date: 2016-08-03
    Description: Optimal control models of biological movements introduce external task factors to specify the pace of movements. Here, we present the dual to the principle of optimality based on a conserved quantity, called “drive,” that represents the influence of internal motivation level on movement pace. Optimal control and drive conservation provide...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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