Publication Date:
1984-09-14
Description:
Exposure to insulin increased stimulus-evoked transmission at synapses formed in culture by cholinergic retinal neurons derived from fetal rats. This effect occurred at physiological concentrations and was long lasting. The findings support the hypothesis that insulin may serve as a developmental signal to regulate the emergence of effective neurotransmission across nascent synapses.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Puro, D G -- Agardh, E -- New York, N.Y. -- Science. 1984 Sep 14;225(4667):1170-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6089343" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Cells, Cultured
;
Insulin/pharmacology/*physiology
;
Muscles
;
Neurons/*growth & development/physiology
;
Parasympathetic Nervous System/physiology
;
Rats
;
Retina
;
Synaptic Transmission
;
Time Factors
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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