Publication Date:
1996-06-28
Description:
T cell proliferation in vivo is presumed to reflect a T cell receptor (TCR)-mediated polyclonal response directed to various environmental antigens. However, the massive proliferation of T cells seen in viral infections is suggestive of a bystander reaction driven by cytokines instead of the TCR. In mice, T cell proliferation in viral infections preferentially affected the CD44hi subset of CD8+ cells and was mimicked by injection of polyinosinic-polycytidylic acid [poly(I:C)], an inducer of type I interferon (IFN I), and also by purified IFN I; such proliferation was not associated with up-regulation of CD69 or CD25 expression, which implies that TCR signaling was not involved. IFN I [poly(I:C)]-stimulated CD8+ cells survived for prolonged periods in vivo and displayed the same phenotype as did long-lived antigen-specific CD8+ cells. IFN I also potentiated the clonal expansion and survival of CD8+ cells responding to specific antigen. Production of IFN I may thus play an important role in the generation and maintenance of specific memory.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tough, D F -- Borrow, P -- Sprent, J -- AI21487/AI/NIAID NIH HHS/ -- CA25803/CA/NCI NIH HHS/ -- CA38355/CA/NCI NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1996 Jun 28;272(5270):1947-50.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Immunology, Scripps Research Institute, La Jolla, California 92037, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8658169" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antigens, CD/analysis
;
Antigens, CD44/analysis
;
Antigens, Differentiation, T-Lymphocyte/analysis
;
CD4-Positive T-Lymphocytes/immunology
;
CD8-Positive T-Lymphocytes/cytology/*immunology
;
Cell Division
;
Cell Survival
;
Immunologic Memory
;
Immunophenotyping
;
Interferon Type I/*immunology/pharmacology
;
Lectins, C-Type
;
*Lymphocyte Activation
;
Lymphocytic Choriomeningitis/*immunology
;
Lymphocytic choriomeningitis virus/*immunology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Transgenic
;
Poly I-C/pharmacology
;
Receptors, Antigen, T-Cell/immunology
;
Receptors, Interleukin-2/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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