Publication Date:
2012-06-23
Description:
Chemokines have a central role in regulating processes essential to the immune function of T cells, such as their migration within lymphoid tissues and targeting of pathogens in sites of inflammation. Here we track T cells using multi-photon microscopy to demonstrate that the chemokine CXCL10 enhances the ability of CD8+ T cells to control the pathogen Toxoplasma gondii in the brains of chronically infected mice. This chemokine boosts T-cell function in two different ways: it maintains the effector T-cell population in the brain and speeds up the average migration speed without changing the nature of the walk statistics. Notably, these statistics are not Brownian; rather, CD8+ T-cell motility in the brain is well described by a generalized Levy walk. According to our model, this unexpected feature enables T cells to find rare targets with more than an order of magnitude more efficiency than Brownian random walkers. Thus, CD8+ T-cell behaviour is similar to Levy strategies reported in organisms ranging from mussels to marine predators and monkeys, and CXCL10 aids T cells in shortening the average time taken to find rare targets.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387349/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3387349/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Harris, Tajie H -- Banigan, Edward J -- Christian, David A -- Konradt, Christoph -- Tait Wojno, Elia D -- Norose, Kazumi -- Wilson, Emma H -- John, Beena -- Weninger, Wolfgang -- Luster, Andrew D -- Liu, Andrea J -- Hunter, Christopher A -- AI-081478/AI/NIAID NIH HHS/ -- AI-090234/AI/NIAID NIH HHS/ -- AI-41158/AI/NIAID NIH HHS/ -- AI-42334/AI/NIAID NIH HHS/ -- CA-069212/CA/NCI NIH HHS/ -- EY-021314/EY/NEI NIH HHS/ -- F32 AI098374/AI/NIAID NIH HHS/ -- F32 AI098374-01/AI/NIAID NIH HHS/ -- R01 AI041158/AI/NIAID NIH HHS/ -- R01 AI041158-14/AI/NIAID NIH HHS/ -- R01 CA069212/CA/NCI NIH HHS/ -- R01 NS072298/NS/NINDS NIH HHS/ -- R21 EY021314/EY/NEI NIH HHS/ -- R21 EY021314-02/EY/NEI NIH HHS/ -- T32 AI007532/AI/NIAID NIH HHS/ -- T32 AI007532-15/AI/NIAID NIH HHS/ -- T32 AR007442/AR/NIAMS NIH HHS/ -- T32 AR007442-25/AR/NIAMS NIH HHS/ -- T32-AI-055400/AI/NIAID NIH HHS/ -- England -- Nature. 2012 Jun 28;486(7404):545-8. doi: 10.1038/nature11098.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 South University Avenue, Philadelphia, Pennsylvania 19104, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22722867" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Brain/immunology/microbiology
;
CD8-Positive T-Lymphocytes/*cytology/*immunology
;
*Cell Movement
;
Chemokine CXCL10/antagonists & inhibitors/genetics/*immunology
;
Female
;
Ligands
;
Male
;
Mice
;
Mice, Inbred C57BL
;
Models, Immunological
;
Receptors, CXCR3/genetics/metabolism
;
Time Factors
;
Toxoplasma/growth & development/immunology
Print ISSN:
0028-0836
Electronic ISSN:
1476-4687
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
,
Natural Sciences in General
,
Physics
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