ISSN:
1365-2109
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
Notes:
The pharmacokinetics and bioavailabilities of 14C-astaxanthin and 14C-canthaxanthin were studied in the blood of rainbow trout following intra-arterial (i.a.) and oral (p.o.) administration. Sixteen months old 1 kg trout were cannulated in the dorsal aorta. [6,7,6′,7′-14C]-keto-carotenoids were administered i.a. and p.o. at a dose of 573.5 kBq kg−1 fish body weight for astaxanthin and 836.2 kBq kg−1 fish body weight for canthaxanthin. After i.a. distribution, total body clearance (Cltot) was 17.30±20.29 mL kg−1 of fish h−1 for 14C-canthaxanthin and 3.30±1.50 mL kg−1 of fish h−1 for 14C-astaxanthin. The volume of distribution at steady-state (Vss) was 208.32±124.79 mL kg−1 of fish and 71.84±64.15 mL kg−1 of fish for 14C-canthaxanthin and 14C-astaxanthin respectively. Less than 0.4% of the administered radioactivity was recovered in urine. Radioactivity (expressed as percent of the dose) excreted in the bile of fish that received 14C-canthaxanthin by i.a. route was 20-fold higher than that observed for fish treated p.o. This ratio was lower for 14C-astaxanthin (7.6-fold). The mean keto-carotenoid bioavailabilities calculated were 10–15% for both compounds. Findings suggest one daily astaxanthin application is preferable, while 12-h time intervals between applications are preferable for canthaxanthin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1365-2109.2005.01375.x
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