ISSN:
1042-7163
Keywords:
Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A convenient synthesis of 1-(8-phosphonomethoxy-3,6-dioxaoctyl) uracil, cytosine, adenine, and guanine nucleotide analogues 26, 28, 30, and 32 by Mitsunobu coupling of the nucleobases with suitably functionalized alcohol derivative 24 is described. The antiviral activity of this series of compounds against herpes simplex virus (HSV) types 1 and 2 and human cytomegalovirus is reported.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hc.520050512
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