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  • 1
    Keywords: mass movements; landslides
    Description / Table of Contents: Introduction --- Subaqueous mass movements in the context of observations of contemporary slope failure / Joshu J. Mountjoy, Aggeliki Georgiopoulou, Jason Chaytor, Michael A. Clare, Davide Gamboa and Jasper Moernaut / Geological Society, London, Special Publications, 500, 1-12, 26 May 2020, https://doi.org/10.1144/SP500-2019-237 --- Section A: consequences and implications --- Revisiting the tsunamigenic volcanic flank collapse of Fogo Island in the Cape Verdes, offshore West Africa / Rachel Barrett, Elodie Lebas, Ricardo Ramalho, Ingo Klaucke, Steffen Kutterolf, Andreas Klügel, Katja Lindhorst, Felix Gross and Sebastian Krastel / Geological Society, London, Special Publications, 500, 13-26, 13 March 2020, https://doi.org/10.1144/SP500-2019-187 --- The sedimentology and tsunamigenic potential of the Byron submarine landslide off New South Wales, Australia / Kendall C. Mollison, Hannah E. Power, Samantha L. Clarke, Alan T. Baxter, Emily M. Lane and Thomas C. T. Hubble / Geological Society, London, Special Publications, 500, 27-40, 7 April 2020, https://doi.org/10.1144/SP500-2019-160 --- Effects of rotational submarine slump dynamics on tsunami genesis: new insight from idealized models and the 1929 Grand Banks event / T. Zengaffinen, F. Løvholt, G. K. Pedersen and C. B. Harbitz / Geological Society, London, Special Publications, 500, 41-61, 11 May 2020, https://doi.org/10.1144/SP500-2019-201 --- A scenario-based assessment of the tsunami hazard in Palermo, northern Sicily, and the southern Tyrrhenian Sea / Jack Dignan, Aaron Micallef, Christof Mueller, Attilio Sulli, Elisabetta Zizzo and Daniele Spatola / Geological Society, London, Special Publications, 500, 63-80, 31 March 2020, https://doi.org/10.1144/SP500-2019-181 --- A workflow for the rapid assessment of the landslide-tsunami hazard in peri-alpine lakes / Michael Strupler, Flavio S. Anselmetti, Michael Hilbe, Katrina Kremer and Stefan Wiemer / Geological Society, London, Special Publications, 500, 81-95, 18 March 2020, https://doi.org/10.1144/SP500-2019-166 --- Towards a national-scale assessment of the subaqueous mass movement hazard in Canada / D. Gwyn Lintern, Jessica Rutherford, Philip R. Hill, Calvin Campbell and Alexandre Normandeau / Geological Society, London, Special Publications, 500, 97-113, 11 May 2020, https://doi.org/10.1144/SP500-2019-206 --- Structural constraints on the subduction of mass-transport deposits in convergent margins / Jacob Geersen, Andrea Festa and Francesca Remitti / Geological Society, London, Special Publications, 500, 115-128, 13 March 2020, https://doi.org/10.1144/SP500-2019-174 --- Evaluating the sealing potential of young and thin mass-transport deposits: Lake Villarrica, Chile / Jasper Moernaut, Gauvain Wiemer, Achim Kopf and Michael Strasser / Geological Society, London, Special Publications, 500, 129-146, 13 March 2020, https://doi.org/10.1144/SP500-2019-155 --- Influence of mass transport deposit (MTD) surface topography on deep-water deposition: an example from a predominantly fine-grained continental margin, New Zealand / Suzanne Bull, Greg H. Browne, Malcolm J. Arnot and Lorna J. Strachan / Geological Society, London, Special Publications, 500, 147-171, 28 April 2020, https://doi.org/10.1144/SP500-2019-192 --- Section B: initiation, triggers and preconditioning --- A multi-disciplinary investigation of the AFEN Slide: the relationship between contourites and submarine landslides / Ricarda Gatter, Michael A. Clare, James E. Hunt, Millie Watts, B. N. Madhusudhan, Peter J. Talling and Katrin Huhn / Geological Society, London, Special Publications, 500, 173-193, 28 April 2020, https://doi.org/10.1144/SP500-2019-184 --- Indonesian Throughflow as a preconditioning mechanism for submarine landslides in the Makassar Strait / Rachel E. Brackenridge, Uisdean Nicholson, Benyamin Sapiie, Dorrik Stow and Dave R. Tappin / Geological Society, London, Special Publications, 500, 195-217, 1 April 2020, https://doi.org/10.1144/SP500-2019-171 --- Morphological signature of gully development by rapid slide retrogression in a layered coarse-grained delta foreslope / Jacques Locat, Ali Azizian, Jim Stronach, Aurélien Hospital, Chris Young, Dominique Turmel and Andrew Bevan / Geological Society, London, Special Publications, 500, 219-234, 13 March 2020, https://doi.org/10.1144/SP500-2019-159 --- Morphology and spatio-temporal distribution of lacustrine mass-transport deposits in Wörthersee, Eastern Alps, Austria / Christoph Daxer, Maddalena Sammartini, Ariana Molenaar, Thomas Piechl, Michael Strasser and Jasper Moernaut / Geological Society, London, Special Publications, 500, 235-254, 19 March 2020, https://doi.org/10.1144/SP500-2019-179 --- A numerical investigation of excess pore pressures and continental slope stability in response to ice-sheet dynamics / Morelia Urlaub, Isabel Kratzke and Berit Oline Hjelstuen / Geological Society, London, Special Publications, 500, 255-266, 13 March 2020, https://doi.org/10.1144/SP500-2019-185 --- Impact of sea-level fluctuations on the sedimentation patterns of the SE African margin: implications for slope instability / Aaron Micallef, Aggeliki Georgiopoulou, Andrew Green and Vittorio Maselli / Geological Society, London, Special Publications, 500, 267-276, 13 March 2020, https://doi.org/10.1144/SP500-2019-172 --- Geomechanical behaviour of gassy soils and implications for submarine slope stability: a literature analysis / P. Kaminski, M. Urlaub, J. Grabe and C. Berndt / Geological Society, London, Special Publications, 500, 277-288, 13 March 2020, https://doi.org/10.1144/SP500-2019-149 --- From gravity cores to overpressure history: the importance of measured sediment physical properties in hydrogeological models / Davide Mencaroni, Jaume Llopart, Roger Urgeles, Sara Lafuerza, Eulàlia Gràcia, Anne Le Friant and Morelia Urlaub / Geological Society, London, Special Publications, 500, 289-300, 22 May 2020, https://doi.org/10.1144/SP500-2019-176 --- The influence of clay content on submarine slope failure: insights from laboratory experiments and numerical models / M. M. W. Silver and B. Dugan / Geological Society, London, Special Publications, 500, 301-309, 26 March 2020, https://doi.org/10.1144/SP500-2019-186 --- Subduction of an extinct rift and its role in the formation of submarine landslides in NW South America / Carlos A. Vargas, Gustavo A. Gutiérrez and Gustavo A. Sarmiento / Geological Society, London, Special Publications, 500, 311-322, 12 May 2020, https://doi.org/10.1144/SP500-2019-189 --- Section C: characterization and regional controls --- Mass wasting on Alpha Ridge in the Arctic Ocean: new insights from multibeam bathymetry and sub-bottom profiler data / Kai Boggild, David C. Mosher, Paola Travaglini, Catalina Gebhardt and Larry Mayer / Geological Society, London, Special Publications, 500, 323-340, 13 May 2020, https://doi.org/10.1144/SP500-2019-196 --- The Last Glacial Maximum Balearic Abyssal Plain megabed revisited / Antonio Cattaneo, Shray Badhani, Cristina Caradonna, Massimo Bellucci, Estelle Leroux, Nathalie Babonneau, Sébastien Garziglia, Jeffrey Poort, Grigorii G. Akhmanov, Germain Bayon, Bernard Dennielou, Gwenäel Jouet, Sébastien Migeon, Marina Rabineau, Laurence Droz and Michael Clare / Geological Society, London, Special Publications, 500, 341-357, 14 May 2020, https://doi.org/10.1144/SP500-2019-188 --- Integrated geophysical, sedimentological and geotechnical investigation of submarine landslides in the Gulf of Lions (Western Mediterranean) / Shray Badhani, Antonio Cattaneo, Stefano Collico, Roger Urgeles, Bernard Dennielou, Estelle Leroux, Florent Colin, Sebastien Garziglia, Marina Rabineau and Laurence Droz / Geological Society, London, Special Publications, 500, 359-376, 14 May 2020, https://doi.org/10.1144/SP500-2019-175 --- Characterization of recent deep-sea debrites in the eastern Mediterranean based on foraminiferal taphonomy / Oded Katz, Leeron Ashkenazi, Shani Sultan-Levi, Sigal Abramovich, Ahuva Almogi-Labin and Orit Hyams-Kaphzan / Geological Society, London, Special Publications, 500, 377-391, 11 May 2020, https://doi.org/10.1144/SP500-2019-170 --- Widespread mass-wasting processes off NE Sicily (Italy): insights from morpho-bathymetric analysis / Daniele Casalbore, Romano Clementucci, Alessandro Bosman, Francesco Latino Chiocci, Eleonora Martorelli and Domenico Ridente / Geological Society, London, Special Publications, 500, 393-403, 15 May 2020, https://doi.org/10.1144/SP500-2019-195 --- Geomorphology and event-stratigraphy of recent mass-movement processes in Lake Hallstatt (UNESCO World Heritage Cultural Landscape, Austria) / Michael Strasser, T. Berberich, S. Fabbri, M. Hilbe, J-J. S. Huang, S. Lauterbach, M. Ortler, H. Rechschreiter, A. Brauer, F. Anselmetti and K. Kowarik / Geological Society, London, Special Publications, 500, 405-426, 31 March 2020, https://doi.org/10.1144/SP500-2019-178 --- Slope stability hazard in a fjord environment: Douglas Channel, Canada / Cooper D. Stacey, D. Gwyn Lintern, John Shaw and Kim W. Conway / Geological Society, London, Special Publications, 500, 427-451, 20 May 2020, https://doi.org/10.1144/SP500-2019-191 --- Submarine canyons, slope failures and mass transport processes in southern Cascadia / Jenna C. Hill, Janet T. Watt, Daniel S. Brothers and Jared W. Kluesner / Geological Society, London, Special Publications, 500, 453-475, 20 May 2020, https://doi.org/10.1144/SP500-2019-169 --- Tectonic and geomorphic controls on the distribution of submarine landslides across active and passive margins, eastern New Zealand / S. J. Watson, J. J. Mountjoy and G. J. Crutchley / Geological Society, London, Special Publications, 500, 477-494, 13 March 2020, https://doi.org/10.1144/SP500-2019-165 --- Geological and tectonic controls on morphometrics of submarine landslides of the Spanish margins / Ricardo León, Roger Urgeles, Raul Pérez-López, Emilio Payo, Amanda Vázquez-Izquierdo, Carmen Julia Giménez-Moreno and David Casas / Geological Society, London, Special Publications, 500, 495-513, 20 May 2020, https://doi.org/10.1144/SP500-2019-153 --- Section D: mobility and kinematics --- Megaclasts within mass-transport deposits: their origin, characteristics and effect on substrates and succeeding flows / Jefferson Nwoko, Ian Kane and Mads Huuse / Geological Society, London, Special Publications, 500, 515-530, 31 March 2020, https://doi.org/10.1144/SP500-2019-146 --- Line length balancing to evaluate multi-phase submarine landslide development: an example from the Storegga Slide, Norway / Suzanne Bull and Joseph A. Cartwright / Geological Society, London, Special Publications, 500, 531-549, 23 March 2020, https://doi.org/10.1144/SP500-2019-168 --- A new depositional model for the Tuaheni Landslide Complex, Hikurangi Margin, New Zealand / Benjamin Couvin, Aggeliki Georgiopoulou, Joshu J. Mountjoy, Lawrence Amy, Gareth J. Crutchley, Morgane Brunet, Sebastian Cardona, Felix Gross, Christoph Böttner, Sebastian Krastel and Ingo Pecher / Geological Society, London, Special Publications, 500, 551-566, 19 May 2020, https://doi.org/10.1144/SP500-2019-180 --- Mass transport deposits in the Donegal Barra Fan and their association with British–Irish Ice Sheet dynamics / Srikumar Roy, Aggeliki Georgiopoulou, Sara Benetti and Fabio Sacchetti / Geological Society, London, Special Publications, 500, 567-586, 18 March 2020, https://doi.org/10.1144/SP500-2019-177 --- Short- and long-term movement of mudflows of the Mississippi River Delta Front and their known and potential impacts on oil and gas infrastructure / Jason D. Chaytor, Wayne E. Baldwin, Samuel J. Bentley, Melanie Damour, Douglas Jones, Jillian Maloney, Michael D. Miner, Jeff Obelcz and Kehui Xu / Geological Society, London, Special Publications, 500, 587-604, 26 March 2020, https://doi.org/10.1144/SP500-2019-183 --- Lessons learned from the monitoring of turbidity currents and guidance for future platform designs / Michael Clare, D. Gwyn Lintern, Kurt Rosenberger, John E. Hughes Clarke, Charles Paull, Roberto Gwiazda, Matthieu J. B. Cartigny, Peter J. Talling, Daniel Perara, Jingping Xu, Daniel Parsons, Ricardo Silva Jacinto and Ronan Apprioual / Geological Society, London, Special Publications, 500, 605-634, 22 May 2020, https://doi.org/10.1144/SP500-2019-173
    Pages: Online-Ressource (VII, 639 Seiten) , Illustrationen, Diagramme, Karten
    ISBN: 9781786204776
    Language: English
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  • 2
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 55 (1990), S. 5854-5861 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of chemical information and modeling 22 (1982), S. 109-113 
    ISSN: 1520-5142
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Perspectives in drug discovery and design 1 (1993), S. 49-68 
    ISSN: 1573-9023
    Keywords: Enzyme ; Inhibitor ; Design ; HIV-1 ; Protease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Close examination of the X-ray crystallographic structures of complexes of prototypical HIV protease inhibitors drawn from diverse structural classes and bound to either synthetic or recombinant HIV protease reveals a remarkable degree of conservation vis-à-vis the protein's homodimeric backbone geometry and key features of its inhibitor binding site. Subtle concerted movements of the amino acid side chains lining this cavity and making contact with inhibitors are evident in exquisite detail in the most highly resolved structures. They are responsible for the enzyme's selectivity. As noted in the preceding perspective on X-ray crystallographic studies, HIV protease is rapidly becoming one of the most well-studied proteins. As a modeler one is encouraged to use the available structural data to predict the binding modes of other classes of HIV protease inhibitors for which X-ray data are unavailable and also as templates to guide the design of further novel inhibitors, which hopefully have some advantages over existing structures. The improvements sought typically involve structural simplification, metabolic stability, or most of all, increased in vivo potency and oral bioavailability. While the structural outcome may or may not bear resemblance to any one of the original reference inhibitor structures, we refer to this process as one ofstructure-based design to emphasize its dependence on critical analyses of the properties and behavior of these experimental datasets. Computational methodologies are available to analyze and compare these datasets in some depth, and to display and manipulate them interactively, in various complementary visualization formats, as a preliminary to undertaking any structurally directed synthetic initiatives. Likewise, efficient molecular-mechanics software tools are on hand to explore the conformational changes around the active site, which are needed to build in or to dock models of new inhibitor structures; either prospectively, for evaluation as potential synthetic targets, or retrospectively, to help rationalize the SAR of a known series or lead in the context of a more realistic active site-bound model. To date these design techniques and strategies have been applied mainly to the optimization of established peptidomimetic leads and to rationalize the binding modes of new peptidomimetic inhibitor classes. However, examples exist of applications to the binding modes of nonpeptidic inhibitors and of limited attempts at de novo structure-based design.
    Type of Medium: Electronic Resource
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  • 9
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Two recent reports have described a polymorphism in HFE (refs 1,2) in the binding region of a PCR primer widely used in diagnosis of hereditary haemochromatosis (HHC). This polymorphism, IVS4+48G/A (originally described by Totaro et al.), is associated with the wild-type allele at the site of ...
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  • 10
    ISSN: 1573-8477
    Keywords: Genetic elements ; estimate ; senescence ; Drosophila
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Although many different physiological and biochemical changes characterize the process of senescence, little is understood of the genetic elements that determine its age of onset. We provide here the first estimates of the number of genetic factors that extend longevity inDrosophila melanogaster. Life span was measured in F1, F2 and backcrosses of true-breeding long and short-lived stocks ofD. melanogaster, established by selection. Estimates of the number of effective factors delaying senescence range from about 0.3 to 1.5, indicating control by a single factor. The distribution of longevity shows this to arise as selection acts on the short-lived parental stock. Life span is extended at the cost of early fecundity.
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