ISSN:
1476-5535
Keywords:
Clean-in-place
;
Automatic cleaning
;
Bioreactors
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Process Engineering, Biotechnology, Nutrition Technology
Notes:
Summary Guidelines for design, validation and operation of clean-in-place systems for industrial fermentation plant are presented. Design of vessels, surface finishes, materials of construction, types and locations of valves are some of the considerations addressed. Requisite levels of turbulence for cleaning of pipes and vessels are discussed as well as typical cleaning sequences. Recommendations for validation of cleaning are presented and the significance of design of cleaning systems in ensuring satisfactory validation is pointed out. To the extent possible, validation of cleaning should be carried out with real process soil or soil closely simulating actual fermentation broths.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01569748
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