Publication Date:
2015-03-19
Description:
Article Receptor Interacting Protein Kinase 2 (RIPK2) mediates innate immune signalling in response to intracellular pathogens, but its aberrant activation contributes to autoimmune pathologies. Here Nachbur et al. describe a RIPK2 inhibitor that is effective in a mouse model of multiple sclerosis. Nature Communications doi: 10.1038/ncomms7442 Authors: Ueli Nachbur, Che A. Stafford, Aleksandra Bankovacki, Yifan Zhan, Lisa M. Lindqvist, Berthe K. Fiil, Yelena Khakham, Hyun-Ja Ko, Jarrod J. Sandow, Hendrik Falk, Jessica K. Holien, Diep Chau, Joanne Hildebrand, James E. Vince, Phillip P. Sharp, Andrew I. Webb, Katherine A. Jackman, Sabrina Mühlen, Catherine L. Kennedy, Kym N. Lowes, James M. Murphy, Mads Gyrd-Hansen, Michael W. Parker, Elizabeth L. Hartland, Andrew M. Lew, David C. S. Huang, Guillaume Lessene, John Silke
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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