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  • 1
    Electronic Resource
    Electronic Resource
    Computer Simulation of Interlayer Molecular Structure in Sodium Montmorillonite Hydrates (1995)
    s.l. : American Chemical Society
    Langmuir 11 (1995), S. 2734-2741 
    Details
    ISSN: 1520-5827
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/la00007a064
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  • 2
    Electronic Resource
    Electronic Resource
    Electrical Properties of a High-T〈sub〉c〈/sub〉 Superconductor-Polymer Compersite (2007)
    s.l. ; Stafa-Zurich, Switzerland
    Materials science forum Vol. 546-549 (May 2007), p. 1989-1992 
    Details
    ISSN: 1662-9752
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: A superconductor-polymer composite of Bi1.8Pb0.4Sr2Ca2Cu3Oy and ethylene propylenerubber (EPR) was prepared by conventional solid-state reaction method. The phase structure of thecomposite was characterized by using x-ray diffraction technique. The resistivity of compositesamples annealed at different temperatures was measured between 40K and 300K. The resultsindicate that the resistivity of the as-prepared composite increases with increasing EPR content andshows essentially a semiconducting behavior above Tc. For fixed EPR content, the resistivity ofcomposite samples decreases with increasing annealing temperature. The composite begins to showsome signs of superconducting transition at an annealing temperature of 700 ºC and zero resistance isreached for samples sintered at 800ºC. Thermal gravimetric analysis (TGA) on the compositeconfirmed that 65% of the EPR content still present in the superconducting composite samples. SEMwas used to investigate the surface morphology of the composites. Preliminary results show that themechanical properties of the composite have been much improved compared with its parentsuperconductor ceramics
    Type of Medium: Electronic Resource
    URL: http://www.tib-hannover.de/fulltexts/2011/0528/02/16/transtech_doi~10.4028%252Fwww.scientific.net%252FMSF.546-549.1989.pdf
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  • 3
    Electronic Resource
    Electronic Resource
    The Crystal Structure and Cytotoxicity of Goniodiol-7-monoacetate from Goniothalamus amuyon (1991)
    s.l. : American Chemical Society
    Journal of natural products 54 (1991), S. 1077-1081 
    Details
    ISSN: 1520-6025
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/np50076a024
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  • 4
    Electronic Resource
    Electronic Resource
    Activation of metabotropic glutamate receptors in conjunction with postsynaptic depolarization triggers a long-term depression of the N-methyl-D-aspartate receptor-mediated synaptic potential in the rat hippocampus (1995)
    Springer
    Journal of biomedical science 2 (1995), S. 166-173 
    Details
    ISSN: 1423-0127
    Keywords: Glutamate receptor ; Long-term depression ; N-Methyl-D-aspartate ; Hippocampus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The mechanism responsible for long-term depression (LTD) of pharmacologically isolated N-methyl-D-aspartate (NMDA) receptor-mediated excitatory postsynaptic potential (EPSPNMDA) was studied. Intracellular recordings were made from CA1 cells of rat hippocampal slices in the presence of 6-cyano-7-nitroquinoxaline-2,3-dione (10 µM) and picrotoxin (50 µM), which block non-NMDA and GABAA receptors, respectively. Intracellular injections of depolarizing pulses (500 ms, 0.3–0.7 nA) at 1 Hz for 5 min in the absence of synaptic stimulation caused a persistent increase in the amplitude of EPSPNMDA. However, coupling postsynaptic depolarization with synaptic activity induced LTD. The EPSPNMDA LTD could be blocked byL-2-amino-3-phosphonopropionic acid (50 µM) or (RS)-α-methyl-4-carboxyphenylglycine (200 µM), specific antagonists for metabotropic glutamate receptors (mGluR). Furthermore, application oftrans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD, 50 µM), a specific mGluR agonist, in conjunction with postsynaptic depolarizing elicited LTD. In contrast, the mGluR agonists quisqualate or t-ACPD when given alone produced a sustained enhancement of EPSPNMDA. Finally, coupled depolarization did not evoke LTD in slices pretreated with the protein kinase C (PKC) inhibitor calphostin c (60 nM). The present results demonstrate that activation of mGluR is necessary for the induction of LTD of EPSPNMDA and suggest that NMDA receptors are subject to bidirectional regulation by mGluR. Furthermore, the induction of LTD is likely to involve the stimulation of PKC.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02253068
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  • 5
    Electronic Resource
    Electronic Resource
    Evidence for Arylamine N-Acetyltransferase Activity in the Escherichia coli (1998)
    Springer
    Current microbiology 36 (1998), S. 125-130 
    Details
    ISSN: 1432-0991
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. N-Acetyltransferase activities with p-aminobenzoic acid and 2-aminofluorene as substrates were determined in isolates of the bacterium Escherichia coli. The N-acetyltransferase activity was determined by an acetyl CoA recycling assay and high pressure liquid chromatography. The N-acetyltransferase activities from a number of E. coli isolates were found to be 0.67 ± 0.04 nmole/min/mg protein for 2-aminofluorene, and 0.46 ± 0.02 nmole/min/mg protein for p-aminobenzoic acid. The apparent K m and V max values obtained were 2.85 ± 0.65 mM and 7.51 ± 0.86 nmol/min/mg protein, respectively, for 2-aminofluorene, and 2.35 ± 0.39 mM and 9.43 ± 0.78 nmol/min/mg protein, respectively, for p-aminobenzoic acid. The optimal pH value for the enzyme activity was 7.0 for both substrates tested. The optimal temperature for enzyme activity was 37°C for both substrates. The N-acetyltransferase activity was inhibited by iodoacetamide: at 0.25 mM iodoacetamide, activity was reduced 50%, and at 1.0 mM, more than 90%. Among a series of divalent cations and salts, Cu2+ and Zn2+ were demonstrated to be the most potent inhibitors. This report is the first demonstration of acetyl CoA:arylamine N-acetyltransferase activity in E. coli.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/PL00006755
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  • 6
    Electronic Resource
    Electronic Resource
    Simultaneous measurement of plasma serotonin, catecholamines, and their metabolites by an in vitro microdialysis-microbore hplc and a dual amperometric detector (1994)
    Weinheim : Wiley-Blackwell
    Electroanalysis 6 (1994), S. 871-877 
    Details
    ISSN: 1040-0397
    Keywords: Dual electrochemical detection ; Neurotransmitter ; Biogenic amine ; Microdialysis ; Highperformance liquid chromatography ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Many advantages of a method for the simultaneous measurement of plasma norepinephrine (NE), epinephrine (E), dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin, and 5-hydroxyindole-3-acetic acid by the in vitro microdialysis-microbore high-performance liquid chromatography-electrochemical detection (MD-MHPLC-ED) technique have been described in our previous article. The present experiment uses a dual electrode electrochemical detector (DUED) in the MD-MHPLC system, providing an additional reliable measurement or assignment of peaks by identifying the peaks based on their redox ratios at the oxidation/reduction cycle. Thus, the important early eluting front and interfering peaks were eliminated on the cathodic chromatogram. Within 15 minutes, an isocratic separation of these analytes is achieved by using microbore column. Hence, theoretically, over 90 analyses can be performed in a single working day. The detection limit (S/N = 3) of this method was about 0.2 to 0.5 pg per injection. The required volume of plasma samples is less than 200 μL. Thus, blood loss is minimal with repeated blood sampling, especially in experiments using small animals. This simple, efficient, and sensitive method can, therefore, be used as a basic research tool in the investigation of blood biogenic amines and their metabolites.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/elan.1140061011
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  • 7
    Electronic Resource
    Electronic Resource
    Burning Behavior of Composite Solid Propellant containing porous ammonium perchlorate (1989)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 14 (1989), S. 108-112 
    Details
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A pilot scale fluidized bed process was developed for preparing porous ammonium perchlorate (PAP) in various particle sizes. The oxidizer, ammonium perchlorate (AP), of composite solid propellant was partially replaced by PAP which was obtained by the fluidization process. The burning rate of propellants containing PAP was found to increase as compared with that of propellants without PAP. In the present study, the effects of percentage content and particle size of PAP incorporated in propellant compositions, on the burning rate were investigated. The results showed that the burning rate increases with increasing of PAP content and with decreasing of PAP particle size for trimodal oxidizer propellants.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prep.19890140305
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  • 8
    Electronic Resource
    Electronic Resource
    Characteristics of Porous Ammonium Perchlorate and propellants containing same (1990)
    Weinheim : Wiley-Blackwell
    Propellants, Explosives, Pyrotechnics 15 (1990), S. 261-265 
    Details
    ISSN: 0721-3115
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Porous ammonium perchlorate (PAP) was prepared by a successfully developed fluidization process at 230°C. The geometric structure of manufactured PAP was characterized by means of a scanning electron microscope (SEM). The physical and mechanical properties of composite propellans containing PAP were also determined. Owing to the diffusion of binder into pores of PAP, the elongation of propellants decreased.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/prep.19900150607
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  • 9
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    Yeast homologous recombination-based promoter engineering for the activation of silent natural product biosynthetic gene clusters (2015)
    National Academy of Sciences
    Details
    Publication Date: 2015-07-06
    Description: Large-scale sequencing of prokaryotic (meta)genomic DNA suggests that most bacterial natural product gene clusters are not expressed under common laboratory culture conditions. Silent gene clusters represent a promising resource for natural product discovery and the development of a new generation of therapeutics. Unfortunately, the characterization of molecules encoded by these clusters is hampered owing to our inability to express these gene clusters in the laboratory. To address this bottleneck, we have developed a promoter-engineering platform to transcriptionally activate silent gene clusters in a model heterologous host. Our approach uses yeast homologous recombination, an auxotrophy complementation-based yeast selection system and sequence orthogonal promoter cassettes to exchange all native promoters in silent gene clusters with constitutively active promoters. As part of this platform, we constructed and validated a set of bidirectional promoter cassettes consisting of orthogonal promoter sequences, Streptomyces ribosome binding sites, and yeast selectable marker genes. Using these tools we demonstrate the ability to simultaneously insert multiple promoter cassettes into a gene cluster, thereby expediting the reengineering process. We apply this method to model active and silent gene clusters (rebeccamycin and tetarimycin) and to the silent, cryptic pseudogene-containing, environmental DNA-derived Lzr gene cluster. Complete promoter refactoring and targeted gene exchange in this “dead” cluster led to the discovery of potent indolotryptoline antiproliferative agents, lazarimides A and B. This potentially scalable and cost-effective promoter reengineering platform should streamline the discovery of natural products from silent natural product biosynthetic gene clusters.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 10
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    Hyponastic Leaves 1 protects pri-miRNAs from nuclear exosome attack (2020)
    National Academy of Sciences
    Details
    Publication Date: 2020-07-07
    Description: Biogenesis of plant microRNAs (miRNAs) takes place in nuclear dicing bodies (D-bodies), where the ribonulease III-type enzyme Dicer-like 1 (DCL1) processes primary transcripts of miRNAs (pri-miRNAs) into miRNA/miRNA* (*, passenger strand) duplexes from either base-to-loop or loop-to-base directions. Hyponastic Leaves 1 (HYL1), a double-stranded RNA-binding protein, is crucial for efficient and accurate processing. However, whether HYL1 has additional function remains unknown. Here, we report that HYL1 plays a noncanonical role in protecting pri-miRNAs from nuclear exosome attack in addition to ensuring processing. Loss of functions in SOP1 or HEN2, two cofactors of the nucleoplasmic exosome, significantly suppressed the morphological phenotypes ofhyl1-2. Remarkably, mature miRNAs generated from loop-to-base processing were partially but preferentially restored in thehyl1 sop1andhyl1 hen2double mutants. Accordingly, loop-to-base–processed pri-miRNAs accumulated to higher levels in double mutants. In addition, dysfunction of HEN2, but not of SOP1, inhyl1-2resulted in overaccumulation of many base-to-loop–processed pri-miRNAs, with most of their respective miRNAs unaffected. In summary, our findings reveal an antagonistic action of exosome in pri-miRNA biogenesis and uncover dual roles of HYL1 in stabilizing and processing of pri-miRNAs.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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