ISSN:
1432-1041
Keywords:
amobarbital
;
drug metabolism
;
population study
;
urinary excretion
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary Most drugs undergo two or more concurrent biotransformation reactions. If these can compensate for each other, pharmacokinetic data concerned solely with the parent drug may hide, rather than reveal, the variability of specific reactions. Hence, there is room for the development of testing procedures, suitable for defining specific drug-metabolizing reactions, and sufficiently simple to allow the testing of numerous subjects or populations. We scrutinized the effects of reducing the collection of urine samples on the reliability of metabolic rate constants, using amobarbital as a model drug. Eight healthy subjects ingested amobarbital, and the rates of urinary excretion of its metabolites were followed for 5 days. Rate constants could be accurately determined using only two 12-h night urines, the second and fifth day after drug intake. Supplementary results obtained by studying additional groups of subjects suggested that a shorter time for urine collection than a 12-h period led to erroneous estimates of the rate constants of metabolite formation. This could be explained partly by a dependence of amobarbital metabolite excretion on urine flow if the flow rates are less than 40 ml/h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00545220
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