ISSN:
1573-904X
Keywords:
buccal delivery
;
diclofenac sodium
;
human clinical
;
hydrogel device
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract The buccal delivery of the nonsteroidal antiinflammatory drug, diclofenac sodium (Voltaren), from a prototype hydrogel was studied in man in a randomized crossover design of buccal delivery and i.v. infusion. After a 30-min delay, plasma levels of diclofenac increased to near steady-state levels of 100 ng/ml by 3 hr. With each subject serving as his own control, the i.v. infusion data facilitated the calculation of a mean steady-state flux of diclofenac sodium of 2.1 ± 0.6 mg/cm2-hr across human buccal mucosa and a time lag of 1.0 ± 0.5 hr. The large flux of this ionized species indicates that the traditional lipoidal model of buccal permeation based on the partition coefficient is inadequate.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1018941517355
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