Publication Date:
2009-08-29
Description:
Adaptation is a central focus of biology, although it can be difficult to identify both the strength and agent of selection and the underlying molecular mechanisms causing change. We studied cryptically colored deer mice living on the Nebraska Sand Hills and show that their light coloration stems from a novel banding pattern on individual hairs produced by an increase in Agouti expression caused by a cis-acting mutation (or mutations), which either is or is closely linked to a single amino acid deletion in Agouti that appears to be under selection. Furthermore, our data suggest that this derived Agouti allele arose de novo after the formation of the Sand Hills. These findings reveal one means by which genetic, developmental, and evolutionary mechanisms can drive rapid adaptation under ecological pressure.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736094/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736094/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Linnen, Catherine R -- Kingsley, Evan P -- Jensen, Jeffrey D -- Hoekstra, Hopi E -- F32 GM083073-02/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2009 Aug 28;325(5944):1095-8. doi: 10.1126/science.1175826.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Organismic and Evolutionary Biology and the Museum of Comparative Zoology, Harvard University, 26 Oxford Street, Cambridge, MA 02138, USA. clinnen@oeb.harvard.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19713521" target="_blank"〉PubMed〈/a〉
Keywords:
Adaptation, Physiological/*genetics
;
Agouti Signaling Protein/chemistry/*genetics
;
*Alleles
;
Animals
;
Crosses, Genetic
;
Ecosystem
;
*Evolution, Molecular
;
Gene Frequency
;
Hair/chemistry/growth & development
;
Hair Color/*genetics
;
Haplotypes
;
Linkage Disequilibrium
;
Melanins/analysis
;
Molecular Sequence Data
;
Mutation
;
Nebraska
;
Peromyscus/*genetics/physiology
;
Phenotype
;
Pigmentation/*genetics
;
Polymorphism, Genetic
;
RNA, Messenger/genetics/metabolism
;
Selection, Genetic
;
Sequence Deletion
;
Serine/genetics
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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