Publication Date:
2010-01-02
Description:
We report the fabrication of devices in which one single-walled carbon nanotube spans a barrier between two fluid reservoirs, enabling direct electrical measurement of ion transport through the tube. A fraction of the tubes pass anomalously high ionic currents. Electrophoretic transport of small single-stranded DNA oligomers through these tubes is marked by large transient increases in ion current and was confirmed by polymerase chain reaction analysis. Each current pulse contains about 10(7) charges, an enormous amplification of the translocated charge. Carbon nanotubes simplify the construction of nanopores, permit new types of electrical measurements, and may open avenues for control of DNA translocation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801077/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801077/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, Haitao -- He, Jin -- Tang, Jinyao -- Liu, Hao -- Pang, Pei -- Cao, Di -- Krstic, Predrag -- Joseph, Sony -- Lindsay, Stuart -- Nuckolls, Colin -- R21 HG004770/HG/NHGRI NIH HHS/ -- R21 HG004770-01/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2010 Jan 1;327(5961):64-7. doi: 10.1126/science.1181799.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Chemistry, Columbia University, New York, NY 10027, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20044570" target="_blank"〉PubMed〈/a〉
Keywords:
*DNA, Single-Stranded
;
Electric Conductivity
;
Electrochemistry
;
Ion Transport
;
Molecular Dynamics Simulation
;
*Nanotubes, Carbon
;
*Oligodeoxyribonucleotides
;
Polymerase Chain Reaction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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