Publication Date:
1997-11-05
Description:
To create mice expressing exclusively human sickle hemoglobin (HbS), transgenic mice expressing human alpha-, gamma-, and betaS-globin were generated and bred with knockout mice that had deletions of the murine alpha- and beta-globin genes. These sickle cell mice have the major features (irreversibly sickled red cells, anemia, multiorgan pathology) found in humans with sickle cell disease and, as such, represent a useful in vivo system to accelerate the development of improved therapies for this common genetic disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paszty, C -- Brion, C M -- Manci, E -- Witkowska, H E -- Stevens, M E -- Mohandas, N -- Rubin, E M -- HL20985/HL/NHLBI NIH HHS/ -- HL31579/HL/NHLBI NIH HHS/ -- N01-HB-07086/HB/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1997 Oct 31;278(5339):876-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Human Genome Center and Department of Subcellular Structure, Lawrence Berkeley National Laboratory, 1 Cyclotron Road (MS 74-157), University of California, Berkeley, CA 94720, USA. c_paszty@csa2.lbl.gov〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9346488" target="_blank"〉PubMed〈/a〉
Keywords:
Anemia, Sickle Cell/*genetics/pathology
;
Animals
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Disease Models, Animal
;
Female
;
Globins/genetics
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Hemoglobin, Sickle/genetics
;
Humans
;
Male
;
Mice
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Mice, Inbred C57BL
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Mice, Knockout
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Mice, Transgenic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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