Publication Date:
2015-01-13
Description:
Resilience to host inflammation and other perturbations is a fundamental property of gut microbial communities, yet the underlying mechanisms are not well understood. We have found that human gut microbes from all dominant phyla are resistant to high levels of inflammation-associated antimicrobial peptides (AMPs) and have identified a mechanism for lipopolysaccharide (LPS) modification in the phylum Bacteroidetes that increases AMP resistance by four orders of magnitude. Bacteroides thetaiotaomicron mutants that fail to remove a single phosphate group from their LPS were displaced from the microbiota during inflammation triggered by pathogen infection. These findings establish a mechanism that determines the stability of prominent members of a healthy microbiota during perturbation.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388331/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388331/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cullen, T W -- Schofield, W B -- Barry, N A -- Putnam, E E -- Rundell, E A -- Trent, M S -- Degnan, P H -- Booth, C J -- Yu, H -- Goodman, A L -- AI064184/AI/NIAID NIH HHS/ -- AI76322/AI/NIAID NIH HHS/ -- DK089121/DK/NIDDK NIH HHS/ -- DP2 GM105456/GM/NIGMS NIH HHS/ -- GM103574/GM/NIGMS NIH HHS/ -- GM105456/GM/NIGMS NIH HHS/ -- R01 GM103574/GM/NIGMS NIH HHS/ -- T32 AI007640/AI/NIAID NIH HHS/ -- UL1 TR000142/TR/NCATS NIH HHS/ -- New York, N.Y. -- Science. 2015 Jan 9;347(6218):170-5. doi: 10.1126/science.1260580.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA. ; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. ; Department of Molecular Biosciences and Institute of Cell and Molecular Biology, University of Texas, Austin, TX 78712, USA. ; Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. ; Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA. ; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI 96813, USA. ; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA. Microbial Sciences Institute, Yale University School of Medicine, New Haven, CT 06520, USA. andrew.goodman@yale.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25574022" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antimicrobial Cationic Peptides
;
Bacteroides/*drug effects/genetics/physiology
;
Colitis/*microbiology
;
Drug Resistance, Bacterial/*genetics
;
Escherichia coli/drug effects/physiology
;
Gastrointestinal Tract/*microbiology
;
Germ-Free Life
;
Humans
;
Lipid A/metabolism
;
Mice
;
Microbiota/*drug effects/genetics/physiology
;
Phosphoric Monoester Hydrolases/genetics/*physiology
;
Polymyxin B/*pharmacology
;
Symbiosis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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