Publication Date:
2002-03-16
Description:
Multidrug-resistant tuberculosis (MDR) is perceived as a growing hazard to human health worldwide. Judgments about the true scale of the problem, and strategies for containing it, need to come from a balanced appraisal of the epidemiological evidence. We conclude in this review that MDR is, and will probably remain, a locally severe problem; that epidemics can be prevented by fully exploiting the potential of standard short-course chemotherapy (SCC) based on cheap and safe first-line drugs; and that best-practice SCC may even reduce the incidence of MDR where it has already become endemic. On the basis of the available, imperfect data, we recommend a three-part response to the threat of MDR: widespread implementation of SCC as the cornerstone of good tuberculosis control, improved resistance testing and surveillance, and the careful introduction of second-line drugs after a sound evaluation of cost, effectiveness, and feasibility.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Dye, Christopher -- Williams, Brian G -- Espinal, Marcos A -- Raviglione, Mario C -- New York, N.Y. -- Science. 2002 Mar 15;295(5562):2042-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Communicable Diseases, World Health Organization, CH-1211 Geneva 27, Switzerland. dyec@who.int〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11896268" target="_blank"〉PubMed〈/a〉
Keywords:
Acquired Immunodeficiency Syndrome/complications
;
Antitubercular Agents/pharmacology/*therapeutic use
;
*Drug Resistance, Multiple, Bacterial
;
Drug Therapy, Combination
;
*Global Health
;
HIV Infections/complications
;
Humans
;
Incidence
;
Mycobacterium tuberculosis/*drug effects/physiology
;
*Tuberculosis, Multidrug-Resistant/drug
;
therapy/epidemiology/microbiology/prevention & control
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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