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  • 1
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    Presentation of a viral T cell epitope expressed in the CDR3 region of a self immunoglobulin molecule (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-01-08
    Description: Synthetic peptides corresponding to microbial epitopes stimulate T cell immunity but their immunogenicity is poor and their half-lives are short. A viral epitope inserted into the complementarity-determining region 3 (CDR3) loop of the heavy chain of a self immunoglobulin (Ig) molecule was generated from the Ig context and was presented by I-Ed class II molecules to virus-specific, CD4+ T cells. Chimeric Ig-peptide was presented 100 to 1000 times more efficiently than free synthetic peptide and was able to prime virus-specific T cells in vivo. These features suggest that antigenized Ig can provide an improved and safe vaccine for the presentation of microbial and other peptides.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zaghouani, H -- Steinman, R -- Nonacs, R -- Shah, H -- Gerhard, W -- Bona, C -- AI13013/AI/NIAID NIH HHS/ -- AI18316/AI/NIAID NIH HHS/ -- AI24460/AI/NIAID NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1993 Jan 8;259(5092):224-7.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7678469" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigen-Presenting Cells/*immunology ; Antigens, Viral/*immunology ; Arsenic/immunology ; *Arsenicals ; Base Sequence ; CD4-Positive T-Lymphocytes/immunology ; DNA/genetics ; Epitopes/*immunology ; Hemagglutinin Glycoproteins, Influenza Virus ; Hemagglutinins, Viral/genetics/immunology ; Histocompatibility Antigens Class II/immunology ; Immunoglobulin Heavy Chains/genetics/immunology ; Immunoglobulin Variable Region/genetics/immunology ; Immunoglobulins/genetics/*immunology ; Mice ; Mice, Inbred BALB C ; Molecular Sequence Data ; Mutagenesis ; Receptors, Fc/immunology ; Recombinant Fusion Proteins/immunology ; Transfection
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
    Electronic Resource
    Electronic Resource
    Dust metrics with comoving constant curvature slices (1992)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 33 (1992), S. 705-711 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: Irrotational dust metrics are considered by requiring the hypersurfaces orthogonal to the matter wordlines to be of constant curvature. The resulting line elements are either contained in the well-known Szekeres dust solutions or they are homogeneous metrics of Bianchi class I or V.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.529805
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  • 3
    Electronic Resource
    Electronic Resource
    Classification of the space-times admitting a constant curvature synchronization (1988)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 29 (1988), S. 327-331 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: A constant curvature synchronization is a foliation of the space-time by spacelike hypersurfaces which are spaces of constant curvature for the induced metric. The classification of the space-times admitting such a synchronization is given according to the dimension and structure of all the isometry groups that can act with orbits tangent to it.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.528071
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  • 4
    Electronic Resource
    Electronic Resource
    FAILURE TO SUPPRESS THETA ANTIGENIC EXPRESSION IN PROGENY DERIVED FROM PRE-IMMUNIZED MATERNAL RECIPIENTS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 3 (1976), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: One possible theory concerning the success of the fetus as an allograft has been attributed to maternal modification of foreign fetal antigenic expression. In this respect progeny derived from pre-immunized maternal mouse recipients, have been examined for any modification (reduction) of corresponding θ antigen determinants. Two major groups of mice were examined. The first group of embryo transplantation derived AKR homozygotes born from pre-immunized CBA recipients whilst producing the corresponding anti-θAKR antibody activity. The second group of naturally derived reciprocal (CBA × AKR)FI heterozygotes were also born from pre-immunized maternal recipients.In neither group was θ expression found to be modified and the significance of this finding is discussed in respect of other situations where fetal antigenic expression is known to be altered by maternal influence.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1976.tb00589.x
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  • 5
    Electronic Resource
    Electronic Resource
    Inhibition of mitogen induced blastogenesis by 5'-deoxy-5'-S-iso-butyl adenosine
    Amsterdam : Elsevier
    Biochemical and Biophysical Research Communications 70 (1976), S. 622-629 
    Details
    ISSN: 0006-291X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/0006-291X(76)91093-7
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  • 6
    Electronic Resource
    Electronic Resource
    Recognition of Altered Autologous Constituents as Foreign by Phagocytic Cells (1967)
    [s.l.] : Nature Publishing Group
    Nature 213 (1967), S. 824-825 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been shown that these "specialized" cells (for example, circulating leucocytes and macrophages of the reticulo-endothelial system) engulf particulate antigens (for example, from microbes, protozoa and red blood and other cells) by means of phagocytosis1'2. They will also take up isolated ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/213824a0
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  • 7
    Electronic Resource
    Electronic Resource
    On the generalization of Szafron solutions of Einstein field equations (1987)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 28 (1987), S. 654-656 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The explicit form of the solutions of the Einstein field equations corresponding to a perfect fluid in geodesic, hypersurface-orthogonal motion is given with the following restrictions: (i) the comoving hypersurfaces are flat; and (ii) the second fundamental form of these surfaces is degenerate. These results are a natural extension of the metrics previously found by Szafron and co-workers [D. A. Szafron and J. Wainwright, J. Math. Phys. 18, 1668 (1977); D. A. Szafron, ibid. 18, 1673 (1977); D. A. Szafron and C. B. Collins, ibid. 20, 2354 (1979)] as a perfect fluid generalization of the Szekeres dust solutions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.527598
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  • 8
    Electronic Resource
    Electronic Resource
    Isometry groups of three-dimensional Lorentzian metrics (1994)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 35 (1994), S. 873-884 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The necessary and sufficient conditions for a three-dimensional Lorentzian metric to admit a group Gr of isometries acting on s-dimensional orbits are given. These conditions are expressed in terms of the eigenvalues and eigenvectors of the Ricci tensor. As a by-product, the set of (abstract) groups that can act isometrically and maximally on such metrics is obtained.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.530618
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  • 9
    Electronic Resource
    Electronic Resource
    A new proof of the generalized Birkhoff theorem (1988)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 29 (1988), S. 1440-1441 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: A new proof of the generalized Birkhoff theorem in general relativity is presented. The partial results contained in previous proofs are recovered in a unified treatment of the different kinds of space-times to which the theorem applies. The proof is based on the fact that these space-times are conformal to the direct product of two two-dimensional manifolds (almost-product structure).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.527936
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  • 10
    Electronic Resource
    Electronic Resource
    Invariant conformal vectors in space-times admitting a group of G3 of motions acting on spacelike orbits S2 (1988)
    College Park, Md. : American Institute of Physics (AIP)
    Journal of Mathematical Physics 29 (1988), S. 2462-2464 
    Details
    ISSN: 1089-7658
    Source: AIP Digital Archive
    Topics: Mathematics , Physics
    Notes: The paper deals with four-dimensional space-times admitting locally a three-dimensional group of motions G3 acting on two-dimensional spacelike orbits S2. The local existence problem for conformal vectors invariant under G3 is shown to be equivalent to the local existence problem for Killing vectors of a given two-dimensional pseudo-Riemannian metric g. This problem is explicitly solved in terms of the Gaussian curvature R of g and two of its scalar differential concomitants. The results are applied to the case of dust-filled space-times, where an exhaustive list of metrics has been obtained by using the algebraic computing language smp. The metrics are either homogeneous, self-similar, or Friedmann models.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.528082
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