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  • 1
    Electronic Resource
    Electronic Resource
    Cell degeneration and elimination in the imaginal wing disc, caused by the mutationsvestigial andUltravestigial ofDrosophila melanogaster (1983)
    Springer
    Development genes and evolution 192 (1983), S. 285-294 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila ; Cell degeneration ; Imaginal disc ; Basal lamina ; Blood cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The mutationsvestigial (vg; recessive) andUltravestigial (vg U; dominant) ofDrosophila melanogaster give rise to identical mutant adult phenotypes in which much of the cases this results from cell death in the presumptive wing margin of the wing disc in the third larval instar, but the process of cell degeneration is quite different in the two mutants. Invg cell death occurs continuously throughout the third larval instar, while invg U it occurs only in the early third instar. Cells fragment and some of the fragments condense, becoming electron dense (“apoptosis”). Both condensed and ultrastructurally normal cell fragments are extruded to the basal side of thevg disc epithelium. They accumulate under the basal lamina in the wing pouch area until they are phagocytosed by blood cells entering the wing pouch during the six hours following pupariation. Fragments are not extruded from thevg U epithelium but are apparently phagocytosed by neighboring epithelial cells. The basal lamina undergoes mophological changes following pupariation and is phagocytosed by blood cells in both wild-type andvestigial, but investigial the degenerated cell fragments are also engulfed by the same blood cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848662
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  • 2
    Electronic Resource
    Electronic Resource
    The effects of X-rays on the proliferation dynamics of cells in the imaginal wing disc ofDrosophila melanogaster (1977)
    Springer
    Development genes and evolution 183 (1977), S. 85-100 
    Details
    ISSN: 1432-041X
    Keywords: Pattern regulation ; Cell death ; Drosophila ; Imaginal discs ; Clonal analysis ; Mitotic recombination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary We report on the size distribution of clones marked by mitotic recombination induced by several different doses of X-rays applied to 72 h oldDrosophila larvae. The results indicate that the radiation significantly reduces the number of cells which undergo normal proliferation in the imaginal wing disc. We estimate that 1000 r reduces by 40–60% the number of cells capable of making a normal contribution to the development of the adult wing. Part of this reduction is due to severe curtailment in the proliferative ability of cells which nevertheless remain capable of adult differentiation; this effect is possibly due to radiation-induced aneuploidy. Cytological evidence suggests that immediate cell death also occurs as a result of radiation doses as low as 100 r. The surviving cells are stimulated to undergo additional proliferation in response to the X-ray damage so that the result is the differentiation of a normal wing.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848779
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  • 3
    Electronic Resource
    Electronic Resource
    Patterns of dye coupling in the imaginal wing disk of Drosophila melanogaster (1985)
    [s.l.] : Nature Publishing Group
    Nature 317 (1985), S. 533-536 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Dye coupling between the cells of the imaginai wing disk was monitored by the iontophoretic injection of either Lucifer yellow CH (rƒf. 6) or fluorescein complexon (Kodak) into one cell while observing the disk with an epifluorescence microscope. Both membrane potential measurements and direct ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/317533a0
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  • 4
    Electronic Resource
    Electronic Resource
    A zone of non-proliferating cells at a lineage restriction boundary in Drosophila (1985)
    [s.l.] : Nature Publishing Group
    Nature 313 (1985), S. 138-141 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] We analysed autoradiographs of serially sectioned imaginal wing disks that were labelled in vitro with tritiated thymidine after explantation from larvae at different stages. Late third-instar wing disks incorporated label in the columnar epithelium, peripodial membrane and adepithelial cells, but ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/313138a0
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  • 5
    Electronic Resource
    Electronic Resource
    Not so new (1993)
    [s.l.] : Nature Publishing Group
    Nature 366 (1993), S. 199-199 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Daedalus (Nature 365, 300; 1993) thinks his "suckercar" is new but in fact it has been built, raced, and twice banned from further racing1. The racing community preferred the more euphonious "hoover car". As in Daedalus's suckercar, real hoover cars used the principle of a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/366199d0
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  • 6
    Electronic Resource
    Electronic Resource
    Genetics: Genetic Analysis of Developmental Mechanisms in Drosophila (1971)
    [s.l.] : Nature Publishing Group
    Nature 234 (1971), S. 187-194 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] WHEN Thomas Hunt Morgan left embryology for genetics he deserted Hydra, planaria, sea urchins and amphibia for Drosophila. The fruit fly was recognized, and still is recognized, as an ideal organism for the study of eukaryote genetics, but it now seems that it will turn out to be equally suitable ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/234187a0
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  • 7
    Electronic Resource
    Electronic Resource
    Intercalary regeneration in imaginal wing disk of Drosophila melanogaster (1976)
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 659-662 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It has been suggested1'2 that the complementarity between regeneration and duplication can be understood if it is assumed that new positional values1 can be generated during growth only in a fixed sequence, a proximal-to-distal sequence in the case of a regenerating limb7. The spatial pattern of ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/259659b0
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  • 8
    Electronic Resource
    Electronic Resource
    dlg–R proteins: modified guanylate kinases (1992)
    [s.l.] : Nature Publishing Group
    Nature genetics 2 (1992), S. 256-257 
    Details
    ISSN: 1546-1718
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Sir — The Drosophila tumour supressor gene dig (lethal(1)discslarge-1)1,2 encodes a membrane-associated 960 amino-acid protein (dlg-A D.m.; Fig. 1) containing a region homologous to yeast guanylate kinase3 (GK S.c.; Fig. 1), the enzyme that transfers phosphate from ATP to GMP, converting it ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/ng1292-256
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  • 9
    Electronic Resource
    Electronic Resource
    Drosophila: Lethal Derangements of Metamorphosis and Modifications of Gene Expression caused by Juvenile Hormone Mimics (1968)
    [s.l.] : Nature Publishing Group
    Nature 220 (1968), S. 393-394 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Larvae were reared aseptically on a defined medium by a procedure described earlier10. Eggs were collected, dechorionated, and sterilized by washing in detergent, and the larvae which had hatched 24 h later were transferred in sterile conditions to tubes containing the medium. The farnesoate ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/220393a0
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  • 10
    Electronic Resource
    Electronic Resource
    Cell proliferation control in Drosophila: Flies are not worms (1996)
    New York, NY : Wiley-Blackwell
    BioEssays 18 (1996), S. 781-784 
    Details
    ISSN: 0265-9247
    Keywords: Life and Medical Sciences ; Cell & Developmental Biology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: The development of organs during animal development requires the allocation of appropriate numbers of cells to each part of the structure. Yet in Drosophila the patterns of cell proliferation can be quite different from one individual to the next, and in fact can be altered experimentally without altering final morphology. The developing pattern seems to control proliferation, rather than the other way around. Even though the pattern of proliferation is variable, there is some order to it. A recent paper(1) shows that small clusters of cells in developing cell populations are in mitotic synchrony, but that the synchrony is transient. What is the significance of this mitotic synchrony?
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bies.950181003
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