ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A method for covalently binding proteins to carboxyl-containing polymers is described. N-Ethyl-5-pheriylisoxazolium-3′-sulfonate is used to form active esters of the carboxyls, which then condense with amine groups on the protein to yield amides. Conjugates of α-chymotrypsin with such polymers have been obtained, with nearly full retention of enzymatic activity in some preparations.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.1967.360050611
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