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  • 1
    Electronic Resource
    Electronic Resource
    APPLICATIONS OF AUTOMATED SIMULTANEOUS DOUBLE FLUORESCENCE (SDF). II. HLA CLASS I PHENOTYPING USING IMMUNOMAGNETICALLY SEPARATED T LYMPHOCYTES (1989)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 16 (1989), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: HLA class I phenotyping was performed using T-lymphocyte populations isolated by immunomagnetic beads (IMBs) coated with monoclonal antibodies with specificity for CD2, CD4 or CD8. The results were compared to those obtained using density gradient-separated lymphocytes (PBL). The typing trays were read by the automated simultaneous double-fluorescence (SDF) technique previously established in our laboratory using an Astroscan 2100 system. The aims of the present study were to establish whether the advantages of IMB lymphocyte separation and automated plate reading by SDF were complementary and whether the results obtained by IMB-SDF and PBL-SDF were concordant.Similarity coefficients for paired results obtained by IMB-SDF and PBL-SDF varied between 0.825 using anti-CD8-coated IMBs and 0.914 using anti-CD4-coated IMBs with a consistent excess of stronger results observed with the PBL-SDF technique. The variations observed did not result in incorrect phenotype assignment but would significantly influence a cross-matching test.These results illustrate the feasibility of using IMB-separated lymphocytes for HLA phenotyping by SDF.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1989.tb00456.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    IMMUNOGLOBULIN ALLOTYPES IN PATIENTS IN END-STAGE RENAL FAILURE (1985)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 12 (1985), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: In a population of 282 Caucasoid patients in end-stage renal failure (ESRF) Gm and Km typing has confirmed a significant increase in the frequency of the Gm1,2,17;21 haplotype. This was confined to an increase in the number of heterozygous Gm(1, 2, 3, 17; 21, 5, 10, 13, 14) individuals. A concomitant decrease in the frequency of presumptive Gm(3, 5, 10, 13, 14) heterozygotes was also confirmed. Analysis of individual renal diseases revealed significant immunoglobulin allotype, phenotype and haplotype frequency deviations in those patients presenting with hypertension, glomerulonephritis or pyelonephritis. The allotype distribution in patients with physical abnormalities of the urinary-genital tract, whether congenital or acquired, was normal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1985.tb00845.x
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  • 3
    Electronic Resource
    Electronic Resource
    PCR-SSO TYPING FOR DR4-Dw SUBTYPES: APPLICATION TO UNRELATED BONE MARROW TRANSPLANT DONOR SELECTION (1991)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 18 (1991), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Thirty-seven DR4-positive patient-unrelated bone marrow donor pairs previously DR/DQ restriction fragment length polymorphism (RFLP) typed and tested in mixed lymphocyte culture (MLC), have been DR4-Dw subtyped retrospectively using sequence specific oligonucleotide probes. We found that DR4-Dw subtyping substantially increased the accuracy of pre-MLC matching and could potentially accelerate donor searches by avoiding unnecessary MLC tests on Dw-mismatched donors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1991.tb00009.x
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  • 4
    Electronic Resource
    Electronic Resource
    Y-antigen killing by T cells of women is restricted by HLA (1977)
    [s.l.] : Nature Publishing Group
    Nature 266 (1977), S. 544-545 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Table 1 Killing pattern of cells from patient Reef, against her own target cells and those from other family members the percentage of isotope release was calculated according to the following formula: Targets HLA compatibility with patient % Killing of CML Donor ? ac* yes 63 18 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/266544a0
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  • 5
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    Critical Parameters Affecting Bias and Variability in Site-Response Analyses Using KiK-net Downhole Array Data (2013)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2013-06-08
    Description: Because of the limited number of strong-motion records that have measured ground response at large strains, any statistical analyses of seismic site-response models subject to strong ground motions are severely limited by a small number of observations. Recent earthquakes in Japan, including the M w  9.0 Tohoku earthquake of March 2011, have substantially increased the observations of strong-motion records that can be used to compare alternative site-response models at large strains and can subsequently provide insight into the accuracy and precision of site-response models. Using the Kiban-Kyoshin network (KiK-net) downhole array data in Japan, we analyze the accuracy (bias) and variability (precision) resulting from common site-response modeling assumptions, and we identify critical parameters that significantly contribute to the uncertainty in site-response analyses. We perform linear and equivalent-linear site-response analyses at 100 KiK-net sites using 3720 ground motions ranging in amplitude from weak to strong; 204 of these records have peak ground accelerations greater than at the ground surface. We find that the maximum shear strain in the soil profile, the observed peak ground acceleration at the ground surface, and the predominant spectral period of the surface ground motion are the best predictors of where the evaluated models become inaccurate and/or imprecise. The peak shear strains beyond which linear analyses become inaccurate in predicting surface pseudospectral accelerations (PSA; presumably as a result of nonlinear soil behavior) are a function of vibration period and are between 0.01% and 0.1% for periods 〈0.5 s. Equivalent-linear analyses become inaccurate at peak strains of ~0.4% over this range of periods. We find that, for the sites and ground motions considered, site-response residuals at spectral periods 〉0.5 s do not display noticeable effects of nonlinear soil behavior. Online Material: Site-specific information and model residuals at 100 KiK-net stations.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America (SSA)
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  • 6
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    A New Zealand-Specific Pseudospectral Acceleration Ground-Motion Prediction Equation for Active Shallow Crustal Earthquakes Based on Foreign Models (2013)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2013-06-08
    Description: The applicability of foreign ground-motion prediction equations (GMPEs) for predicting geometric-mean pseudospectral acceleration amplitudes from active shallow crustal earthquakes in New Zealand (NZ) is examined. Four different foreign GMPEs were considered, as well as the NZ-based McVerry et al. (2006) (McV06) model. It was found that the McV06 model exhibited the lowest applicability with a database of 2437 recorded ground motions, and that the Chiou et al. (2010) (C10) modification of the Chiou and Youngs (2008b) (CY08) model was the most applicable. Discrepancies between the C10 model and the NZ database, which were empirically identified and theoretically justified, were used to modify the C10 model for: (1) small magnitude scaling; (2) scaling of short period ground motion from normal faulting events in volcanic crust; (3) scaling of ground motions on very hard rock sites; (4) anelastic attenuation in the NZ crust; and (5) consideration of the increased anelastic attenuation in the Taupo Volcanic Zone. The developed NZ-specific model therefore contains features as evident from recorded ground motions in NZ and consistent scaling for parameters not well constrained by NZ data. Comparisons with ground motions from the 4 September 2010 Darfield and 22 February 2011 Christchurch earthquakes, which occurred following completion of the NZ-specific model, illustrate that it provides an empirical prediction with sufficient accuracy and precision.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America (SSA)
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  • 7
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    Recurrent liquefaction in Christchurch, New Zealand, during the Canterbury earthquake sequence (2013)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2013-03-22
    Description: Continuous observational monitoring of a study site in eastern Christchurch, New Zealand, following the 2010 M w 7.1 Darfield earthquake has recorded ten distinct liquefaction episodes in the mainshock–aftershock sequence. Three nearby accelerometers allow calibration between the geological expressions of liquefaction and the intensity of earthquake-induced surface ground motion at the site. Sand blow formation was generated by M w 5.2–7.1 earthquakes with M w 7.5–normalized peak ground accelerations (PGA 7.5 ) of ≥ 0.057 g (acceleration due to gravity). Silt drapes between successive sand blow deposits provide markers for delineating distinct liquefaction-inducing earthquakes in the geologic record. However, erosion quickly modifies the surface of sand blows into alluvial and aeolian forms that complicate geologic diagnosis. The two feeder-dike generations identified in subsurface investigations significantly underrepresent the number of liquefaction-inducing earthquakes due to extensive dike reactivation. New constitutive equations enable PGA 7.5 variations to be estimated from the thickness and areal extent of sand blows.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 8
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    Loss of Bardet Biedl syndrome proteins causes defects in peripheral sensory innervation and function (2007)
    National Academy of Sciences
    Details
    Publication Date: 2007-10-24
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 9
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    Consideration and Propagation of Epistemic Uncertainties in New Zealand Probabilistic Seismic-Hazard Analysis (2012)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2012-08-01
    Description: This article presents results from the consideration of epistemic uncertainties in New Zealand (NZ) probabilistic seismic-hazard analysis. Uncertainties in ground-motion prediction are accounted for via multiple ground-motion prediction equations within the logic-tree framework. Uncertainties in the fault-based seismicity of the earthquake rupture forecast due to uncertainties in fault geometry, slip parameters, and magnitude-scaling relationships are considered in a Monte Carlo simulation framework. Because of the present lack of fault-specific data quantifying uncertainties for many faults in NZ, representative values based on judgement and available data for NZ and foreign faults were utilized. Uncertainties in the modelling of background seismicity were not considered. The implications of the considered epistemic uncertainties in terms of earthquake magnitude–frequency distributions and probabilistic seismic-hazard analyses for two spectral acceleration ordinates, two soil classes, and two locations (Wellington and Christchurch) are examined. The results illustrate that, for the uncertainties considered, the variation in seismic hazard due to the adopted ground-motion prediction model is larger than that due to the uncertainties in the earthquake rupture forecast. Of the earthquake rupture forecast uncertainties considered, the magnitude-geometry scaling relationships was the most significant, followed by fault rupture length. Hence, the obtained results provide useful guidance on which modelling issues are the most critical in the reliability of seismic-hazard analyses for locations in NZ.
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America (SSA)
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  • 10
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    Ground-Motion Observations from the 14 November 2016 Mw 7.8 Kaikoura, New Zealand, Earthquake and Insights from Broadband Simulations (2017)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2017-04-27
    Description: This article provides insights into the observed ground-motion records from the 14 November 2016 M w  7.8 Kaikoura earthquake. Specific detail is given in examining observations in the near source and those in the urban Wellington and Lower Hutt regions through a combination of time series and response spectra to help in understanding salient source, path, and site effects. Several ground motions exceeding 1.0 g horizontal are recorded, as well as up to 2.7 g in the vertical direction at one location. The complexity associated with multifault rupture is clearly evident in several strong-motion stations in the near-source region. Significant site-effect case histories from sedimentary and reclaimed soil deposits and topographic effects are observed in the Wellington and Lower Hutt regions. To provide further insights, predictions from preliminary broadband ground-motion simulations are examined to more directly interpret the observations.
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Published by Seismological Society of America (SSA)
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