ISSN:
1432-072X
Keywords:
Candida albicans
;
Tetaine
;
Inhibition
;
Chitin
;
Mannoprotein
;
Dimorphism
;
Secretion of mannoproteins
;
Yeast spheroplast regeneration
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Abstract The antibiotic tetaine inhibits in Candida albicans the biosynthesis of two important cell wall constituents, chitin and mannoprotein. This effect is a consequence of inactivation of the enzyme glucosamine-6-phosphate synthetase. Due to the lack of glucosamine-6-phosphate the effective secretion of mannoprotein enzymes, acid phosphatase and invertase, by Candida albicans spheroplasts is inhibited. In the presence of tetaine, probably a modified mannoprotein, lacking a branched polymannan, is synthesized. The antibiotic action decreases the viability of Candida albicans cells, especially that of mycelial forms of this fungus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00443651
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