ISSN:
1420-9071
Keywords:
Tamoxifen
;
sex determination
;
alligators
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Tamoxifen is an anticancer drug widely used in the treatment of estrogen-dependent breast cancer. In hatchling alligators it acts as a pure antiestrogen in that it completely blocks the effect of estradiol-induced oviductal hypertrophy and completely blocks the estradiol-induced hepatic vitellogenin secretion. Paradoxically, when injected into alligator eggs incubated at 33°C, a temperature which would normally result in 100% male hatchlings, tamoxifen ‘sex reverses’ the embryos into apparently normal female hatchlings.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01958155
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