ISSN:
1432-1041
Keywords:
Debrisoquine
;
Genetic polymorphism
;
CYP2D6
;
drug metabolism
;
pharmacogenetics
;
Poland
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract The genetic polymorphism of drug oxidation mediated by cytochrome P450IID6 (CYP2D6) was determined in 154 Polish volunteers using debrisoquine as the test substance. The results showed a bimodal distribution of the debrisoquine metabolic ratio (MR). Nine persons (5.8%) with MR〉12.6 were classified as poor metabolisers (gene frequency 0.242), which is in substantial agreement with the data reported for other Caucasian populations.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00193702
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