ISSN:
0739-4462
Keywords:
6-hydroxydopa
;
lepidoptera
;
neuropeptide amidation
;
pyrroloquinoline quinone
;
2,4,5-trihydroxyphenylalanine
;
Chemistry
;
Food Science, Agricultural, Medicinal and Pharmaceutical Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
Notes:
A peptidylglycine α-amidating monooxygenase (PAM) has been characterized in the tobacco hornworm Manduca sexta. Although such enzymes have been well studied in vertebrates, their presence in invertebrates has not been reported. PAM activity was measured in several insect tissues. The highest specific activity was found in the brain. In this organ, PAM activity was high during the larval stages, but low at the end of metamorphosis. Copper, oxygen, and ascorbate were required for activity. Evidence that 2, 4, 5-trihydroxyphenylalanine may be involved in PAM activity is presented. © 1992 Wiley-Liss, Inc.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/arch.940210207
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