ISSN:
1573-4935
Keywords:
chlorpromazine
;
epirubicin
;
bleomycin
;
cytotoxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
Notes:
Abstract The effect of the antiemetic chlorpromazine on bleomycin- and epirubicin cytotoxicity was testedin vitro. Chlorpromazine (0.1 or 0.01 mg/l) enhanced epirubicin-induced toxicity to cultured Chinese fibroblasts whereas 0.01 mg/l chlorpromazine inhibited the cytotoxicity of bleomycin. The results encourage further studies on the effects of commonly used antiemetics on the cytotoxicity and antitumoral effects of anticancer chemotherapeutics.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01116576
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