ISSN:
1573-8221
Keywords:
immunotoxin
;
monoclonal antibodies
;
T cells
;
Jurkat cells
;
K-562 cells
;
cytolytic activity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract Synthesis and properties of an immunotoxin produced by conjugating ricin with a novel monoclonal antibody (IgG3 of the ICO-104 class) are described. Cytolytic activity of the synthesized immunotoxin, determined by two independent methods and expressed in LD50, is 0.3–0.6×10−7 M. Its specificity for target cells containing the CD5 antigen is shown.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02445936
Permalink