ISSN:
0170-2041
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Description / Table of Contents:
Configuration of 2-Amino-4-hydroxy-4-(5-hydroxy-2-pyridyl)-3-methylbutyric Acid, the N-Terminal Amino Acid of the NikkomycinsThe N-ethylthio(thiocarbonyl)derivative 2 of the N-terminal amino acid 1 of the nikkomycin antibiotics shows a positive Cotton effect in its circular dichroism spectrum and therefore 1 is assigned to the L-series. The relative configuration of the C atoms 3 and 4 was ascertained by 1H-NMR investigations and crystal structure analysis. Accordingly, 1 is assigned the configuration 2S,3S,4S.
Notes:
Das N-Ethylthio(thiocarbonyl)derivat 2 der N-terminalen Aminosäure 1 der Nikkomycin-Antibiotika weist Circulardichroismus mit positivem Cottoneffekt auf und 1 ist daher der L-Reihe zu-zuordnen. Die relative Konfiguration an den C-Atomen 3 und 4 wurde durch 1H-NMR- und Kristallstrukturuntersuchungen bestimmt. Danach hat 1 die Konfiguration 2S,3S,4S.
Additional Material:
3 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jlac.198019801112
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