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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 546 (1988), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 546 (1988), S. 0 
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
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  • 3
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The value of any kind of data is greatly enhanced when it exists in a form that allows it to be integrated with other data. One approach to integration is through the annotation of multiple bodies of data using common controlled vocabularies or 'ontologies'. Unfortunately, the very success of this ...
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  • 4
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 236 (1972), S. 152-155 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Fibroblasts in mass cultures generate self-maintaining parallel arrays. In the presence of accumulated collagen, arrays migrate over one another to build meta-stable orthogonal multilayers. The cell partaking in these interactions is the fibroblast in the bipolar spindle form, which does not ...
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Journal of heuristics 5 (1999), S. 53-70 
    ISSN: 1572-9397
    Keywords: flow shop scheduling ; sequence-dependent setup times ; heuristics ; traveling salesman problem
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Abstract This paper presents an enhanced heuristic for minimizing the makespan of the flow shop scheduling problem with sequence-dependent setup times. The procedure transforms an instance of the problem into an instance of the traveling salesman problem by introducing a cost function that penalizes for both large setup times and bad fitness of schedule. This hybrid cost function is an improvement over earlier approaches that penalized for setup times only, ignoring the flow shop aspect of the problem. To establish good parameter values, each component of the heuristic was evaluated computationally over a wide range of problem instances. In the testing stage, an experimental comparison with a greedy randomized adaptive search procedure revealed the conditions and data attributes where the proposed procedure works best.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    International journal of flexible manufacturing systems 6 (1994), S. 5-31 
    ISSN: 1572-9370
    Keywords: printed circuit board assembly ; surface mount technology ; quadratic integer programming ; dynamic programming
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Populating printed circuit boards is one of the most costly and time-consuming steps in electronics assembly. At the beginning of each work order, three decisions are required: (1) a sequence must be specified for placing the individual components on the board; (2) tape reels must be assigned to positions on the magazine rack; and (3) a retrieval plan must be determined should the same component type be assigned to more than one magazine slot. Collectively, these problems can be modeled as a nonlinear integer program. In this paper, we develop a series of algorithms for solving each using an iterative two step approach. Initially, a placement sequence is generated with a weighted, nearest neighbor traveling salesman problem (TSP) heuristic; the two remaining problems are then formulated as a quadratic integer program and solved with a Lagrangian relaxation scheme. As a final step, the current magazine assignments are used to update the placement sequence, and the entire process is repeated. Our ability to deal, at least in part, with simultaneous machine operations represents the major contribution of this work. The methodology was simulated for a set of boards obtained from Texas Instruments and theoretically compared with a heuristic currently in use.
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    International journal of flexible manufacturing systems 9 (1997), S. 251-272 
    ISSN: 1572-9370
    Keywords: approximation ; assembly lines ; NP-completeness ; product sequencing
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Notes: Abstract Mixed-model assembly lines are becoming increasingly interesting as the use of just-in-time principles in manufacturing continues to expand. This paper presents, for the first time, complexity results for the underlying problem of product sequencing. It is shown that the problem is intractable for both the single station and the multiple station case. Nevertheless, efficient 1.5-approximation algorithms are developed for the early- and late-start models associated with the former case. Empirical results demonstrate that these algorithms perform extremely well in practice.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Annals of operations research 34 (1992), S. 149-162 
    ISSN: 1572-9338
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics , Economics
    Notes: Abstract The bilevel programming problem (BLPP) is a two-person nonzero sum game in which play is sequential and cooperation is not permitted. In this paper, we examine a class of BLPPs where the leader controls a set of continuous and discrete variables and tries to minimize a convex nonlinear objective function. The follower's objective function is a convex quadratic in a continuous decision space. All constraints are assumed to be linear. A branch and bound algorithm is developed that finds global optima. The main purpose of this paper is to identify efficient branching rules, and to determine the computational burden of the numeric procedures. Extensive test results are reported. We close by showing that it is not readily possible to extend the algorithm to the more general case involving integer follower variables.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Mathematical programming 40 (1988), S. 15-27 
    ISSN: 1436-4646
    Keywords: Bilevel programming ; Stackelberg games ; branch and bound ; active set strategy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract In this paper a model for a two-level planning problem is presented in the form of a static Stackelberg game. By assumption, play is sequential and noncooperative; however, the leader can influence the actions of the followers through a set of coordination variables while the followers' responses may partly determine the leader's payoff. Under certain convexity assumptions, it is shown that the feasible region induced by the leader is continuous in the original problem variables. This observation, coupled with two corollary results, are used as a basis for a hybrid algorithm which clings to the inducible region until a local optimum is found. A branching scheme is then employed to located other segments of the region, eventually terminating with the global optimum. A number of examples are given to highlight the results, while the algorithm's performance is tested in a comparison with two other procedures.
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  • 10
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 353 (1991), S. 378-378 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - At this large Medical Research Council (MRC) unit where I am director of studies, we interview many prospective graduate students and ask them to talk about their honours projects. The standard is impressive and derives from the students having learnt a wide range of skills in completing a ...
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