ISSN:
1432-1041
Keywords:
theophylline
;
serum concentration
;
sustained-release dosage form
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
,
Medicine
Notes:
Summary The pharmacokinetics and relative bioavailability of theophylline from a new sustained-release formulation (Theotard®) and from a standard sustained-release formulation (Theo-Dur®) were compared in 6 healthy, adult, male volunteers. After a single oral dose of 300 mg Theotard, a mean maximal plasma concentration (Cbmax of 3.49±1.05 mg/l was obtained after 8 h (tmax). After an identical dose of Theo-Dur, a peak plasma concentration of 4.68±1.33 mg/l was obtained after 6.33 h. The mean relative bioavailability of theophylline from Theotard was 1.02±0.16 relative to that of Theo-Dur. In 5 of the volunteers the Theotard formulation exhibited a more prolonged and uniform absorption rate and yielded more sustained plasma levels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00548775
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