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  • 1
    Electronic Resource
    Electronic Resource
    Apoptosis in fatal Ebola infection. Does the virus toll the bell for immune system? (2000)
    Springer
    Apoptosis 5 (2000), S. 5-7 
    Details
    ISSN: 1573-675X
    Keywords: Apoptosis ; cytokines ; cytotoxic T cells ; Ebola virus ; macrophages.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In fatal Ebola virus hemorrhagic fever massive intravascular apoptosis develops rapidly following infection and progressing relentlessly until death. While data suggest that T lymphocytes are mainly deleted by apoptosis in PBMC of human fatal cases, experimental Ebola infection in animal models have shown some evidence of destruction of lymphocytes in spleen and lymph nodes probably involving both T and B cells. Nevertheless, we are able to conclude from the accumulated evidence that early interactions between Ebola virus and the immune system, probably via macrophages, main targets for viral replication, lead to massive destruction of immune cells in fatal cases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1009657006550
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    Paper (German National Licenses)
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  • 2
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    Probing large intraplate earthquakes at the west flank of the Andes (2014)
    Geological Society of America (GSA)
    In: Geology
    Details
    Publication Date: 2014-11-25
    Description: Estimating the potential for the occurrence of large earthquakes on slow-slip-rate faults in continental interiors, away from plate boundaries, is possible only if the long-term geological record of past events is available. However, our knowledge of strong earthquakes appears to be incomplete for thrust faults flanking large actively growing mountain ranges, such as those surrounding Tibet and the Andes Mountains. We present a paleoseismic study of a prominent fault scarp at the west flank of the Andes in Santiago, Chile. The evidence demonstrates recurrent faulting with displacement of ~5 m in each event. With two large earthquake ruptures within the past 17–19 k.y., and the last event occurring ~8 k.y. ago, the fault appears to be ripe for another large earthquake (moment magnitude, M w 7.5). These results emphasize the potential danger of intraplate continental faults, particularly those associated with youthful mountain fronts.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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  • 3
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    Present-day deformation of the Pyrenees revealed by GPS surveying and earthquake focal mechanisms until 2011 (2015)
    Oxford University Press
    Details
    Publication Date: 2015-03-25
    Description: The Pyrenean mountain range is a slowly deforming belt with continuous and moderate seismic activity. To quantify its deformation field, we present the velocity field estimated from a GPS survey of the Pyrenees spanning 18 yr. The PotSis and ResPyr networks, including a total of 85 GPS sites, were installed and first measured in 1992 and 1995–1997, respectively, and remeasured in 2008 and 2010. We obtain a deformation field with velocities less than 1 mm yr –1 across the range. The estimated velocities for individual stations do not differ significantly from zero with 95 per cent confidence. Even so, we estimate a maximum extensional horizontal strain rate of 2.0 ± 1.7 nanostrain per year in a N–S direction in the western part of the range. We do not interpret the vertical displacements due to their large uncertainties. In order to compare the horizontal strain rates with the seismic activity, we analyse a set of 194 focal mechanisms using three methods: (i) the ‘r’ factor relating their P and T axes, (ii) the stress tensors obtained by fault slip inversion and (iii) the strain-rate tensors. Stress and strain-rate tensors are estimated for: (i) the whole data set, (ii) the eastern and western parts of the range separately, and (iii) eight zones, which are defined based on the seismicity and the tectonic patterns of the Pyrenees. Each of these analyses reveals a lateral variation of the deformation style from compression and extension in the east to extension and strike-slip in the west of the range. Although the horizontal components of the strain-rate tensors estimated from the seismic data are slightly smaller in magnitude than those computed from the GPS velocity field, they are consistent within the 2 uncertainties. Furthermore, the orientations of their principal axes agree with the mapped active faults.
    Keywords: Geodynamics and Tectonics
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Deutsche Geophysikalische Gesellschaft (DGG) and the Royal Astronomical Society (RAS).
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  • 4
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    Publisher Correction: A database of the coseismic effects following the 30 October 2016 Norcia earthquake in Central Italy (2019)
    Springer Nature
    Details
    Publication Date: 2019
    Electronic ISSN: 2052-4463
    Topics: Nature of Science, Research, Systems of Higher Education, Museum Science
    Published by Springer Nature
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  • 5
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    Updated seismotectonic zoning scheme of Metropolitan France, with reference to geologic and seismotectonic data (2013)
    Societe Geologique de France (SGF)
    Details
    Publication Date: 2013-05-30
    Description: This work presents the seismotectonic zoning scheme of Metropolitan France developed by the IRSN (French Institute for Radioprotection and Nuclear Safety) within the framework of its seismic hazard assessment activities. It is the outcome of many years of work following the publication of the "seismotectonic atlas" in 1993 [ Grellet et al ., 1993 ]. This scheme supports the assessment of seismic hazard by IRSN. It takes into account the most recent data concerning the deep and surface geology, as well as those related to seismotectonics and tectonic activity. It finally includes 67 surface seismotectonic zones (STZ), as well as a catalogue of 74 faults or structures (named hereafter "potential active faults") for which indications of Neogene to Quaternary displacement can be inferred. The description of the zoning scheme comes along with an estimation of the uncertainty on the boundary location between adjacent STZ. We also qualitatively determine a "relevance order" for each limit, so as to illustrate their reliability to separate regions of different seismogenic potential. Also, we attributed to the faults an indication whose purpose is to reflect the recent character of their activity, and thus their seismotectonic potential. This assessment of uncertainties was undertaken to better integrate the zoning scheme in the general approach, which arises from recent studies, namely the propagation of the uncertainties in seismic hazard evaluation, whether deterministic or probabilistic.
    Print ISSN: 0037-9409
    Electronic ISSN: 0037-9409
    Topics: Geosciences
    Published by Societe Geologique de France (SGF)
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  • 6
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    A Worldwide and Unified Database of Surface Ruptures (SURE) for Fault Displacement Hazard Analyses (2019)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉Abstract〈/div〉Fault displacement hazard assessment is based on empirical relationships that are established using historic earthquake fault ruptures. These relationships evaluate the likelihood of coseismic surface slip considering on‐fault and off‐fault ruptures, for given earthquake magnitude and distance to fault. Moreover, they allow predicting the amount of fault slip at and close to the active fault of concern. Applications of this approach include land use planning, structural design of infrastructure, and critical facilities located on or close to an active fault.To date, the current equations are based on sparsely populated datasets, including a limited number of pre‐2000 events. In 2015, an international effort started to constitute a worldwide and unified fault displacement database (SUrface Ruptures due to Earthquakes [SURE]) to improve further hazard estimations. After two workshops, it was decided to unify the existing datasets (field‐based slip measurements) to incorporate recent and future cases, and to include new parameters relevant to properly describe the rupture.This contribution presents the status of the SURE database and delineates some perspectives to improve the surface‐faulting assessment. Original data have been compiled and adapted to the structure. The database encompasses 45 earthquakes from magnitude 5–7.9, with more than 15,000 coseismic surface deformation observations (including slip measurements) and 56,000 of rupture segments. Twenty earthquake cases are from Japan, 15 from United States, two from Mexico, Italy, and New Zealand, one from Kyrgystan, Ecuador, Turkey, and Argentina. Twenty‐four earthquakes are strike‐slip faulting events, 11 are normal or normal oblique, and 10 are reverse faulting.To pursue the momentum, the initial and common implementation effort needs to be continued and coordinated, and the maintenance and longevity of the database must be guaranteed. This effort must remain based on a large and open community of earthquake geologists to create a free and open access database.〈/span〉
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Published by Seismological Society of America (SSA)
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  • 7
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    A Worldwide and Unified Database of Surface Ruptures (SURE) for Fault Displacement Hazard Analyses (2019)
    Seismological Society of America (SSA)
    Details
    Publication Date: 2019
    Description: 〈span〉〈div〉ABSTRACT〈/div〉Fault displacement hazard assessment is based on empirical relationships that are established using historic earthquake fault ruptures. These relationships evaluate the likelihood of coseismic surface slip considering on‐fault and off‐fault ruptures, for given earthquake magnitude and distance to fault. Moreover, they allow predicting the amount of fault slip at and close to the active fault of concern. Applications of this approach include land use planning, structural design of infrastructure, and critical facilities located on or close to an active fault.To date, the current equations are based on sparsely populated datasets, including a limited number of pre‐2000 events. In 2015, an international effort started to constitute a worldwide and unified fault displacement database (SUrface Ruptures due to Earthquakes [SURE]) to improve further hazard estimations. After two workshops, it was decided to unify the existing datasets (field‐based slip measurements) to incorporate recent and future cases, and to include new parameters relevant to properly describe the rupture.This contribution presents the status of the SURE database and delineates some perspectives to improve the surface‐faulting assessment. Original data have been compiled and adapted to the structure. The database encompasses 45 earthquakes from magnitude 5–7.9, with more than 15,000 coseismic surface deformation observations (including slip measurements) and 56,000 of rupture segments. Twenty earthquake cases are from Japan, 15 from United States, two from Mexico, Italy, and New Zealand, one from Kyrgystan, Ecuador, Turkey, and Argentina. Twenty‐four earthquakes are strike‐slip faulting events, 11 are normal or normal oblique, and 10 are reverse faulting.To pursue the momentum, the initial and common implementation effort needs to be continued and coordinated, and the maintenance and longevity of the database must be guaranteed. This effort must remain based on a large and open community of earthquake geologists to create a free and open access database.〈/span〉
    Print ISSN: 0895-0695
    Electronic ISSN: 1938-2057
    Topics: Geosciences
    Published by Seismological Society of America (SSA)
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  • 8
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    A New Seismic Hazard Model for Ecuador (2018)
    Seismological Society of America
    Details
    Publication Date: 2018-04-03
    Print ISSN: 0037-1106
    Electronic ISSN: 1943-3573
    Topics: Geosciences , Physics
    Published by Seismological Society of America
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  • 9
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    Seismogenic potential of the High Durance Fault constrained by 20 yr of GNSS measurements in the Western European Alps (2020)
    Oxford University Press
    Details
    Publication Date: 2020-06-15
    Description: SUMMARY Due to the steady moderate seismicity observed along the Briançon seismic arc, in the south-western French Alps, three temporary GNSS (Global Navigation Satellite System) surveys took place in 1996, 2006 and 2011, across a ∼50 × 60 km² wide area, to investigate the surface deformation field. The horizontal velocity field computed from these three surveys showed an east–west extension in the network. A fourth campaign was led in 2016, creating a 20 yr observation span, resulting in measurements which reach a sufficient accuracy to assess whether extension found within the Briançon network is localized onto any particular tectonic feature. Several faults in this area are known to be active normal faults. Assessing the localization of the deformation may lead to a better understanding of the active tectonics of the Alpine belt. To address this issue, a robust velocity field was computed from the combination of the different campaign and permanent GNSS data. Strain rate tensors were derived for the first time in this area on a 0.1 × 0.1 deg grid to assess the distribution of the deformation. The regional deformation appears localized in the Briançon area and reaches up to 20 ± 5 nanostrain yr−1 in the centre of the network. The observed velocities were projected on a profile across the network and compared with modelled interseismic deformation to characterize the behaviour of the major active faults known in the study zone. While a two-fault model provides the best fit to the data, a single fault model has only marginally higher residuals, with parameters which are more consistent with the seismotectonics of the region. The localization of the single modelled fault is consistent with the location of the High Durance Fault (HDF). Therefore, we used the known geological location of this structure as a priori information in a block model to compute a fault slip rate at the interface between the two blocks. The velocities on the interface indicate 0.4–0.5 mm yr−1 of extension, and therefore strain accumulates along the HDF throughout the seismic cycle. The geodetically derived fault slip rate is converted into an equivalent seismic moment release rate, which is consistent within its uncertainty bounds with the known historical and instrumental seismicity of the Briançon area.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Royal Astronomical Society.
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  • 10
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    Geodetic evidence for shallow creep along the Quito fault, Ecuador (2019)
    Oxford University Press
    Details
    Publication Date: 2019-12-16
    Description: Quito, the capital city of Ecuador hosting ∼2 million inhabitants, lies on the hanging wall of a ∼60-km-long reverse fault offsetting the Inter-Andean Valley in the northern Andes. Such an active fault poses a significant risk, enhanced by the high density of population and overall poor building construction quality. Here, we constrain the present-day strain accumulation associated with the Quito fault with new Global Positioning System (GPS) data and Persistent Scatterer Interferometric Synthetic Aperture Radar (PS-InSAR) analysis. Far field GPS data indicate 3–5 mm yr–1 of horizontal shortening accommodated across the fault system. In the central segment of the fault, both GPS and PS-InSAR results highlight a sharp velocity gradient, which attests for creep taking place along the shallowest portion of the fault. Smoother velocity gradients observed along the other segments indicate that the amount of shallow creep decreases north and south of the central segment. 2-D elastic models using GPS horizontal velocity indicate very shallow (〈1 km) locking depth for the central segment, increasing to a few kilometres south and north of it. Including InSAR results in the inversion requires locking to vary both along dip and along strike. 3-D spatially variable locking models show that shallow creep occurs along the central 20-km-long segment. North and south of the central segment, the interseismic coupling is less resolved, and data still allows significant slip deficit to accumulate. Using the interseismic moment deficit buildup resulting from our inversions and the seismicity rate, we estimate recurrence time for magnitude 6.5 + earthquake to be between 200 and 1200 yr. Finally, PS-InSAR time-series identify a 2 cm transient deformation that occurred on a secondary thrust, east of the main Quito fault between 1995 and 1997.
    Print ISSN: 0956-540X
    Electronic ISSN: 1365-246X
    Topics: Geosciences
    Published by Oxford University Press on behalf of The Royal Astronomical Society.
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