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  • 1
    Electronic Resource
    Electronic Resource
    The influence of graft size on the induction of immunity versus tolerance to H-Y in H-2 k strains of mice (1985)
    Springer
    Immunogenetics 22 (1985), S. 585-591 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Unprimed female CBA mice do not reject large (10 mm2) syngeneic male skin grafts. However, a high proportion do reject small (4 mm2) grafts. Nevertheless, rejection does not invariably result in an anamnestic response. In some cases, the immunity induced by the rejection of a small graft was overcome, and tolerance was induced by a subsequent challenge with a large graft. This suggests that the transplantation response to minor antigens is subject to active regulation, and screening of other H-2 k strains indicates that the nature of the response (i. e., immunity or tolerance) is determined by a gene or genes mapping outside the major histocompatibility complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00430306
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  • 2
    Electronic Resource
    Electronic Resource
    Primary immune responses to H-Y in BALB/c-H-2 k mice (1983)
    Springer
    Immunogenetics 18 (1983), S. 125-129 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Female mice of the H-2 k haplotype have been thought not to reject primary grafts of male skin. However, most BALB/c-H-2 k female mice bred in our colony rejected syngeneic male grafts. Graft rejection was sufficient to prime the mice for the subsequent generation of H-Y-specific cytotoxic T cells and delayed-type hypersensitivity responses.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00368540
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  • 3
    Electronic Resource
    Electronic Resource
    Mouse candidiasis (1987)
    Springer
    Immunogenetics 25 (1987), S. 200-203 
    Details
    ISSN: 1432-1211
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Administration of a Thy-1.2-specific monoclonal antibody to BALB/c mice resulted in a significant decrease in the efficiency of clearance of Candida albicans from the spleen. The rate of clearance of organisms from the spleen of congenic mice was determined by genes in the major histocompatibility complex, as was the magnitude of the inflammatory response in the popliteal lymph node after footpad immunization. These results formally demonstrate the involvement of T cells in host responses to primary candida infection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00344035
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  • 4
    Electronic Resource
    Electronic Resource
    MURINE CANDIDIASIS: III. HOST INFLAMMATORY RESPONSES ARE REGULATED IN PART BY CLASS I MHC GENES (1987)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 14 (1987), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Host responses to experimental Candida albicans infection in mice have been shown previously to be regulated by genes in the major histocompatibility complex (MHC). Results reported here show that at least part of this control can be mapped to class I MHC genes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1987.tb00397.x
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  • 5
    Electronic Resource
    Electronic Resource
    VARIATION IN H-2 ANTIGEN EXPRESSION ON LYMPHOMYELOID CELLS IN SEMI-ALLOGENEIC IRRADIATION CHIMERAS (1984)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of immunogenetics 11 (1984), S. 0 
    Details
    ISSN: 1744-313X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Spleen cells from 30 individual murine irradiation chimeras of the type (P1 x P2)F1→ P1 were compared in a rosetting assay for H-2K and H-2D cell surface antigen expression with normal (P1 x P2)F1 hybrid controls. Eleven out of the 30 chimeras were in the normal range, but the other 19 differed from F1 controls by 4- to 100-fold in endpoint titre for at least one H-2K or H-2D antigen. Every possible class of variation was found, i.e. up or down variation of H-2K or H-2D antigens of P1 or P2 type. This evidence, together with data from T6 chromosome marker experiments which also showed full reconstitution of lethally irradiated P1 recipients by (P1 x P2)F1 donor lymphomyloid stem cells, suggested that incomplete reconstitution was not the cause of H-2 antigenic variation.Low expression of P2 H-2 antigens on spleen cells derived from (P1 x P2)F1→ P1 chimeras was investigated further. Fifteen lethally irradiated (P1 x P2)F1 recipients of bone marrow cells from two such chimeras were all of normal F1 H-2 phenotype when tested 10-12 weeks after reconstitution, thus excluding stable, low P2 H-2-expressing variant F1 stem cells as a cause of the phenomenon. If P1 recipients were hyperimmunized against P2 cells before lethal irradiation and reconstitution with (P1 x P2)F1 stem cells, there were significantly fewer Till-McCulloch colonies in their spleens 10 days after reconstitution than in spleens of unimmunized controls. Also 〉 90% of immunized recients died by 6 weeks after stem cell injection but two survivors both showed very low levels of P2 H-2K and H-2D antigens. These results together with previously published evidence of anti-P2 Tc cell activity and P2 skin graft rejection in (P1 x P2)F1→ P1 chimeras suggested that residual anti-P2 immunological capability in lethally irradiated P1 recipients may be associated with low P2 H-2 expression on their F1-derived spleen cells, although the mechanism does not involve selection of stable, variant F1 stem cells. The mechanism(s) of other classes of variation in H-2 expression in (P1 x P2)F1→ P1 chimeras were not investigated.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1744-313X.1984.tb01048.x
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  • 6
    Electronic Resource
    Electronic Resource
    Heart (1944)
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Physiology 6 (1944), S. 319-348 
    Details
    ISSN: 0066-4278
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Medicine , Biology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1146/annurev.ph.06.030144.001535
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  • 7
    Electronic Resource
    Electronic Resource
    Cryopreservation of porcine embryos (1995)
    [s.l.] : Nature Publishing Group
    Nature 374 (1995), S. 416-416 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SIR - Cryopreservation of mammalian embryos has important implications for the long-term storage, propagation and transport of valuable genotypes of agricul-tural or zoological interest, and also for in vitro fertilization programmes in humans. The birth of live offspring from embryos frozen in ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/374416a0
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  • 8
    Electronic Resource
    Electronic Resource
    Relationship of the virulence of Trichomonas vaginalis and the major histocompatibility complex in murine trichomonad infection (1996)
    Springer
    Parasitology research 82 (1996), S. 628-633 
    Details
    ISSN: 1432-1955
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract  A biological assay based upon the induction of abscesses in mice injected subcutaneously with Trichomonas vaginalis was shown to be a valid method for comparing the virulence of two isolates of T. vaginalis cultured from two patients, one suffering from severe vaginitis and the other exhibiting only mild disease. The data showed excellent correlation between the physical dimensions of abscesses in mice injected with each trichomonad isolate and the severity of vaginitis produced in the women from whom the isolates were obtained. The assay employed in our study incorporated measurement of the mean abscess volumes from day 1 to day 6 post-inoculation with T. vaginalis. We found that the abscess assay was clearly superior to a murine intraperitoneal assay for virulence evaluation of trichomonad isolates. We then used the murine abscess assay to determine the susceptibility of different strains of mice to infection with a virulent T. vaginalis isolate so as to test whether the genetic constitution of the host would influence the pathogenesis of the disease. BALB/c (H-2d) mice were susceptible to infection with T. vaginalis, but both CBA/CaH (H-2k) and BALB/c-H-2k mice were shown to be resistant. The quantitation of abscess formation in these inbred and congeneic resistant mouse strains demonstrates that the severity of infection with T. vaginalis is governed by genes mapping within the major histocompatibility complex.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004360050176
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  • 9
    Electronic Resource
    Electronic Resource
    Permeation and diffusion of environmental pollutants through flexible polymers (1989)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 38 (1989), S. 227-236 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Permeation and diffusion characteristics of high density polyethylene (HDPE), elasticized polyolefin, and polychloroprene membranes have been determined for various organic pollutants at 22 and 50°C. A standard ASTM permeation cell method was used to measure the permeation rate while an immersion/weight gain method was used to obtain the diffusion coefficient. Thickness-dependent permeation rates were determined for HDPE membranes. An equimolar mixture of various permeants was also used to see the possibility of synergistic effects by combination of permeants. The experimental results are discussed in relation to the suitability of HDPE membranes in severe environments.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1989.070380203
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  • 10
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    Antigens and immune responses in Candida albicans infection (1990)
    Wiley
    Details
    Publication Date: 1990-02-01
    Print ISSN: 0818-9641
    Electronic ISSN: 1440-1711
    Topics: Biology , Medicine
    Published by Wiley
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