ISSN:
1573-8221
Keywords:
experimental tetanus
;
acetylcholinesterase
;
muscarinic cholinolytics
;
acetylcholinesterase reactivators
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The therapeutic efficacy of acetylcholinesterase reactivators dipyroxime and isonitrozin, and also of the central cholinolytics benactyzine and adiphenine, was studied in experiments on rabbits with tetanus produced by intravenous injection of one lethal dose of tetanus toxin. Dipyroxime in a dose of 25 mg/kg had no therapeutic action, and in doses of up to 30–40 mg/kg caused death of the animals. Benactyzine and adiphenine, in a dose of 3–4 mg/kg, abolished tonic convulsions for 1.5–2 h, and isonitrozin in a dose of 25 mg/kg did so for 4–5 h. After combined administration of reactivators and cholinolytics, convulsions were abolished for 4–5 h.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00801298
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