ISSN:
1573-9171
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Conclusions 1. A tricyclic ansa ketolactone, containing a thiophene ring, and specifically 8-methyl-2,3-benzo-5-oxa[10]-α-cyclothien-1,4-dione, was synthesized. The reductive desulfurization of this ketone gives the corresponding ketolactone, hydroxylactone, and lactone, which contain the bicyclic didesoxysearalane skeleton, in various ratios depending on the reaction conditions. 2. It was established by PMR spectroscopy that the insertion of a methyl substituent in the polymethylene bridge suppresses the conformational mobility of the ansa system.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00958823
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