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  • 1
    Electronic Resource
    Electronic Resource
    Comparative haemodynamic dose-response effects of intravenous propranolol and pindolol in patients with coronary heart disease (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 157-165 
    Details
    ISSN: 1432-1041
    Keywords: coronary heart disease ; beta-blockade ; haemodynamics ; propranolol ; pindolol ; intrinsic sympathomimetic activity ; partial agonist activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary To determine whether the depression of left ventricular pumping activity associated with beta-blockade alone could be offset by a substantial degree of partial agonist activity, the haemodynamic dose-response effects of intravenous propranolol and pindolol were compared in a randomised between-group saline controlled study in twenty patients with angiographically proven coronary artery disease. The intravenous doses of propranolol (2–16 mg) and pindolol (0.2–1.6 mg) used were selected on the basis of published reports of equivalence in terms of exercise blockade of chronotropic beta-adrenoceptors. Following four intravenous boluses of each drug, administered according to a cumulative log-dosage schedule, there was a log-linear increase in the plasma concentrations of each drug. The range of plasma concentrations achieved were those which have been shown to be associated with substantial attenuation of sympathetic stimulation of cardiac beta-adrenoceptors. At rest propranolol resulted in dose-related linear reductions in heart rate and cardiac output and linear increases in left heart filling pressure and systemic vascular resistance compared with saline-controlled measurements. The only statistically significant change at rest after pindolol was a small increase in the left heart filling pressure. The calculated systemic vascular resistance was increased after propranolol but unchanged after pindolol. During supine bicycle exercise the systolic blood pressure increased less after propranolol than after saline or pindolol. The increments in all other measured haemodynamic variables during exercise were equally influenced by the two drugs. Propranolol resulted in a significantly greater depression of the relationship between left heart filling pressure and cardiac output at rest and during exercise than an equivalent beta-blocking dose of pindolol. The contrasting haemodynamic profile of the two drugs is explicable by the partial agonist stimulation of the heart by pindolol directly maintaining left ventricular pumping activity and simultaneously lowering afterload by stimulating vasodilator beta2-adrenoceptors in peripheral arteriolar resistance vessels. In patients with impairment of left ventricular function due to coronary heart disease who require intravenous beta-blocking therapy, partial agonist activity in a beta-blocking drug may be haemodynamically advantageous.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00543785
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  • 2
    Electronic Resource
    Electronic Resource
    Is the intrinsic sympathomimetic activity (ISA) of beta-blocking compounds relevant in acute myocardial infarction? (1984)
    Springer
    European journal of clinical pharmacology 27 (1984), S. 509-515 
    Details
    ISSN: 1432-1041
    Keywords: beta-receptor blocking drugs ; myocardial infarction ; haemodynamic effects ; propranolol ; pindolol ; intrinsic sympathomimetic activity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The relevance of the intrinsic sympathomimetic activity (ISA) of beta-blocking compounds to the clinical therapeutics of acute myocardial infarction was evaluated in 20 patients with an uncomplicated acute myocardial infarction by comparing the haemodynamic effects of equivalent beta-blocking doses of propranolol (non-cardioselective; no ISA) and pindolol (non-cardioselective; 50% ISA). Consecutive eligible male patients admitted to a Coronary Care Unit were randomised following a 1 h control period to two separate studies. In Study 1 the short-term dose-response effects of propranolol (1–8 mg) or pindolol (0.1–0.8 mg) were assessed. In Study 2 comparison of the effects of single i.v. propranolol (8 mg) and pindolol (0.8 mg) doses was undertaken over 6 h. Haemodynamic variables and thermodilution cardiac output were subsequently recorded to compare the effects of each drug on the circulation. The plasma concentrations of propranolol and pindolol were in the recognised therapeutic range. Both drugs were clinically well-tolerated, the changes induced in haemodynamic variables following each drug demonstrated effective beta-blockade. Within the limits of the experimental protocol, these data did not suggest definite haemodynamic advantage for ISA of pindolol in acute myocardial infarction. These findings are perhaps due to sympathetic activation in acute myocardial infarction attenuating the haemodynamic impact of ISA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00556884
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  • 3
    Electronic Resource
    Electronic Resource
    The fermi surface properties of vanadium
    Amsterdam : Elsevier
    Physica B: Physics of Condensed Matter 179 (1992), S. 257-263 
    Details
    ISSN: 0921-4526
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Physics
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0921-4526(92)90024-M
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  • 4
    Electronic Resource
    Electronic Resource
    Electronic and optical properties of BaTiO3 and SrTiO3 (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 90 (2001), S. 1854-1859 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have used the linear muffin-tin-orbital method, without geometrical approximations, to calculate the electronic structure of tetragonal BaTiO3 and cubic SrTiO3. Using our self-consistent potential, we have calculated the frequency-dependent dielectric function and the reflectivity spectrum. For tetragonal BaTiO3 the anisotropic optical properties are calculated. We compare our calculations with experimental data and find good agreement. We analyze the origin of the different calculated features in the optical spectra by means of our energy-band structure. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1384862
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  • 5
    Electronic Resource
    Electronic Resource
    Materials science The hardest known oxide (2001)
    [s.l.] : Nature Publishing Group
    Nature 410 (2001), S. 653-654 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A material as hard as diamond or cubic boron nitride has yet to be identified, but here we report the discovery of a cotunnite-structured titanium oxide which represents the hardest oxide known. This is a new polymorph of titanium dioxide, where titanium is nine-coordinated to oxygen in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/35070650
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  • 6
    Electronic Resource
    Electronic Resource
    Development of an in situ ultra-high-vacuum scanning tunneling microscope in the beamline of the 15 MV tandem accelerator for studies of surface modification by a swift heavy ion beam (2001)
    [S.l.] : American Institute of Physics (AIP)
    Review of Scientific Instruments 72 (2001), S. 3884-3890 
    Details
    ISSN: 1089-7623
    Source: AIP Digital Archive
    Topics: Physics , Electrical Engineering, Measurement and Control Technology
    Notes: We report the installation and testing of an ultra-high-vacuum (UHV) scanning tunneling microscope (STM) in the beamline for materials science studies of the 15 MV Pelletron accelerator at the Nuclear Science Center (NSC), New Delhi. This is a new facility for in situ irradiation-induced surface modification studies, available in an accelerator laboratory. The article describes its vibration isolation, in-vacuum sample transfer and other salient features for integrating the STM to the beamline. The UHV STM is tested by obtaining atomically resolved images of highly oriented pyrolytic graphite (HOPG). In situ topographic and spectroscopic studies of defect structures produced by impact of 200 MeV Au ions on HOPG, p-type Si, and 200 MeV Ag-irradiated Y1Ba2Cu3O7+δ are studied. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1405791
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  • 7
    Electronic Resource
    Electronic Resource
    Theoretical prediction of the Cmca phase in Ge under high pressure (2001)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 89 (2001), S. 2547-2549 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have performed first-principles self-consistent total-energy calculations within the local-density approximation using the full-potential linear-muffin-tin-orbital method to investigate crystal structures at high pressure in Ge. We predict a crystallographic phase transition from the simple hexagonal structure to the Cmca phase, which is similar to the Si–VI phase which has recently been observed by Hanfland et al. [Phys. Rev. Lett. 82, 1197 (1999)]. Our calculated pressure for this phase transition is around 94 GPa in Ge. Further, at the very high pressure of about 150 GPa, the Cmca phase is predicted to transform into the hexagonal-close-packed phase. © 2001 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1341215
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  • 8
    Electronic Resource
    Electronic Resource
    Optical properties of 4H–SiC (2002)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 91 (2002), S. 2099-2103 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: The optical band gap energy and the dielectric functions of n-type 4H–SiC have been investigated experimentally by transmission spectroscopy and spectroscopic ellipsometry and theoretically by an ab initio full-potential linear muffin-tin-orbital method. We present the real and imaginary parts of the dielectric functions, resolved into the transverse and longitudinal photon moment a, and we show that the anisotropy is small in 4H–SiC. The measurements and the calculations fall closely together in a wide range of energies. © 2002 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1429766
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  • 9
    Electronic Resource
    Electronic Resource
    Electronic structure of Ti3SiC2 (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 76 (2000), S. 2226-2228 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have investigated the electronic structure of Ti3SiC2 by means of first-principles self-consistent total-energy calculations within the local-density approximation using the full-potential linear-muffin-tin-orbital method. Our calculated volume is in good agreement (within 4%) with experiment. Also, the calculated values for c/a and positional parameters are in excellent agreement with the experimental data. We have compared the electronic structure of Ti3SiC2 with TiC. Our calculations show that Ti3SiC2 has a chemical bonding similar to the one of TiC, which is predominantly covalent. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.126304
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  • 10
    Electronic Resource
    Electronic Resource
    Elastic and high pressure properties of ZnO (1998)
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 83 (1998), S. 8065-8067 
    Details
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We have studied the elastic and structural properties of ZnO by means of accurate first-principles total energy calculations using the full potential linear muffin tin orbital method. The calculations are based on the density functional theory and we have used the local density Hedin–Lundqvist parametrization and the generalized gradient approximation of Perdew and Wang for the exchange and correlation potential. The calculated values for the equilibrium volume, bulk modulus, and elastic constants are generally in very good agreement with experiments. At elevated pressures ZnO undergoes a structural phase transition from the relatively open wurtzite structure into the more dense NaCl atomic arrangement. The calculated transition pressure is in good agreement with experiment. © 1998 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.367901
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