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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Biochemistry 19 (1980), S. 5625-5631 
    ISSN: 1520-4995
    Source: ACS Legacy Archives
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Palo Alto, Calif. : Annual Reviews
    Annual Review of Biochemistry 67 (1998), S. 199-225 
    ISSN: 0066-4154
    Source: Annual Reviews Electronic Back Volume Collection 1932-2001ff
    Topics: Chemistry and Pharmacology , Biology
    Notes: Abstract The cell biology of caveolae is a rapidly growing area of biomedical research. Caveolae are known primarily for their ability to transport molecules across endothelial cells, but modern cellular techniques have dramatically extended our view of caveolae. They form a unique endocytic and exocytic compartment at the surface of most cells and are capable of importing molecules and delivering them to specific locations within the cell, exporting molecules to extracellular space, and compartmentalizing a variety of signaling activities. They are not simply an endocytic device with a peculiar membrane shape but constitute an entire membrane system with multiple functions essential for the cell. Specific diseases attack this system: Pathogens have been identified that use it as a means of gaining entrance to the cell. Trying to understand the full range of functions of caveolae challenges our basic instincts about the cell.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 37 (1989), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: Seismic data often contain traces that are dominated by noise; these traces should be removed (edited) before multichannel filtering or stacking. Noise bursts and spikes should be edited before single channel filtering. Spikes can be edited using a running median filter with a threshold; noise bursts can be edited by comparing the amplitudes of each trace to those of traces that are nearby in offset-common midpoint space. Relative amplitude decay rates of traces are diagnostic of their signal-to-noise (S/N) ratios and can be used to define trace editing criteria. The relative amplitude decay rate is calculated by comparing the time-gated trace amplitudes to a control function that is the median trace amplitude as a function of time, offset, and common midpoint. The editing threshold is set using a data-adaptive procedure that analyses a histogram of the amplitude decay rates.A performance evaluation shows that the algorithm makes slightly fewer incorrect trace editing decisions than human editors. The procedure for threshold setting achieves a good balance between preserving the fold of the data and removing the noisiest traces. Tests using a synthetic seismic line show that the relative amplitude decay rates are diagnostic of the traces’S/N ratios. However, the S/N ratios cannot be accurately usefully estimated at the start of processing, where noisy-trace editing is most needed; this is the fundamental limit to the accuracy of noisy trace editing.When trace equalization is omitted from the processing flow (as in amplitude-versus-offset analysis), precise noisy-trace editing is critical. The S/N ratio of the stack is more sensitive to type 2 errors (failing to reject noisy traces) than it is to type 1 errors (rejecting good traces). However, as the fold of the data decreases, the S/N ratio of the stack becomes increasingly sensitive to type 1 errors.
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Geophysical prospecting 38 (1990), S. 0 
    ISSN: 1365-2478
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences , Physics
    Notes: The signal-to-noise (S/N) ratio of seismic reflection data can be significantly enhanced by stacking. However, stacking using the arithmetic mean (straight stacking) does not maximize the S/N ratio of the stack if there are trace-to-trace variations in the S/N ratio. In this case, the S/N ratio of the stack is maximized by weighting each trace by its signal amplitude divided by its noise power, provided the noise is stationary. We estimate these optimum weights using two criteria: the amplitude-decay rate and the measured noise amplitude for each trace. The amplitude-decay rates are measured relative to the median amplitude-decay rate as a function of midpoint and offset. The noise amplitudes are measured using the data before the first seismic arrivals or at late record times. The optimum stacking weights are estimated from these two quantities using an empirical equation.Tests with synthetic data show that, even after noisy-trace editing, the S/N ratio of the weighted stack can be more than 10 dB greater than the S/N ratio of the straight stack, but only a few decibels more than the S/N ratio of the trace equalized stack. When the S/N ratio is close to 0 dB, a difference of 4 dB is clearly visible to the eye, but a difference of 1 dB or less is not visible. In many cases the S/N ratio of the trace-equalized stack is only a few decibels less than that of the optimum stack, so there is little to be gained from weighted stacking. However, when noisy-trace editing is omitted, the S/N ratio of the weighted stack can be more than 10 dB greater than that of the trace-equalized stack. Tests using field data show that the results from straight stacking, trace-equalized stacking, and weighted stacking are often indistinguishable, but weighted stacking can yield slight improvements on isolated portions of the data.
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  • 5
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 326 (1987), S. 77-79 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] DAMP (3-(2,4-dinitroanilino)-3'-amino-N-methyldipropyl-amine) accumulates in acidic compartments and can be localized in plastic-embedded tissue sections with an antibody against dinitrophenol (DNP)5. To visualize acidic compartments in exocrine pancreatic cells by indirect immunofluorescence, ...
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  • 6
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] A domain in the low-density lipoprotein receptor contains three cysteine-rich 'growth factor' repeats like those that occur in many proteins. When this domain is deleted, the receptor no longer releases its ligand at acid pH, it is no longer recycled efficiently and it is rapidly degraded after ...
    Type of Medium: Electronic Resource
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  • 7
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] TABLE 1 Differential properties of synaptotagmins Ca2+-dependent binding Ca2+-dependent binding Ca2+-independent Tissue of phospholipids of syntaxin binding of AP2 distribution C2-A C2-A/B C2-A C2-A/B C2-A/B Sytl Rostral brain 3-6 nM 3-6 ^M 200^00 ^M 200-400 nM ...
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    [s.l.] : Nature Publishing Group
    Nature 279 (1979), S. 679-685 
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Proteins and peptides can enter cells by receptor-mediated endocytosis, a coupled process by which selected extracellular proteins or peptides are first bound to specific cell surface receptors and then rapidly internalised by the cell Internalisation follows clustering of the receptors in ...
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  • 9
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Low density lipoprotein is taken up by cultured human fibroblasts through an endocytic process that requires the binding of the lipoprotein to specific receptors located in coated pits on the cell surface. The coated pits are discrete segments of the plasma membrane that can undergo rapid ...
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  • 10
    ISSN: 1573-2657
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Histidine-rich calcium binding protein (HRC) is a luminal sarcoplasmic reticulum protein abundant in skeletal and cardiac muscle. Using immunofluorescence to examine non-muscle tissues, we now show that HRC is also abundant in the smooth muscle cells lining the walls of small arteries and arterioles. Arterioles that contain only one or two layers of smooth muscle cells are very brightly stained while small muscular arteries demonstrate a lesser degree of immunoreactivity only in cells just adjacent to the lumen of the vessel. In contrast, visceral smooth muscle cells from the gastrointestinal and genitourinary tracts show no HRC immunofluorescence. We also examined the subcellular distribution of HRC in arteriolar smooth muscle by immunoelectron microscopy. HRC was found in electron-dense vesicles beneath the plasma membrane, in small electron-lucent vesicles and in the nuclear envelope, suggesting a location within a calcium-sequestering compartment. These findings suggest that HRC plays a role in sarcoplasmic reticulum function that is unique to striated and arteriolar smooth muscle.
    Type of Medium: Electronic Resource
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