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  • 1
    Electronic Resource
    Electronic Resource
    FUNDAMENTAL ASPECTS OF SELECTIVE TOXICITY (1965)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 123 (1965), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1965.tb12241.x
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  • 2
    Electronic Resource
    Electronic Resource
    Resolution of a Racemic Pteridine during Paper Chromatography (1963)
    [s.l.] : Nature Publishing Group
    Nature 199 (1963), S. 1098-1099 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When a larger quantity (50 mg) was chromatographed on a column of cellulose (diameter 4.7, and length 120 cm), two fractions were obtained which, after recrystallization from boiling water, were found to have the same four pKa values and ultra-violet spectra as the material prior to chromatography. ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1991098a0
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  • 3
    Electronic Resource
    Electronic Resource
    Stability of Metal Complexes of Oxine and its Sulphonic Acid (1959)
    [s.l.] : Nature Publishing Group
    Nature 184 (1959), S. 449-449 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When a comparison is made between results obtained in the same solvent, it is seen that the presence of the sulphonic acid group has only a small effect on the stability constants. This is clearly shown by the typical values (Table 1), all of which were obtained in water at 20-25. TABLE 1 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/184449a0
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  • 4
    Electronic Resource
    Electronic Resource
    Mode of Action of Isoniazid (1956)
    [s.l.] : Nature Publishing Group
    Nature 177 (1956), S. 525-526 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] In order to form metal complexes, for example, (III), isoniazid must first form the anion (II), which is the chelating species. No anion can be formed by 1-tsonicotinyl-l-methylhydrazine (I, R = CH3). This substance has recently been synthesized and found to be virtually inactive3, thus giving ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/177525a0
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  • 5
    Electronic Resource
    Electronic Resource
    Avidity of the Tetracyclines for the Cations of Metals (1956)
    [s.l.] : Nature Publishing Group
    Nature 177 (1956), S. 433-434 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Ionization Constants. Tetracycline hydrochloride, dried for an hour in air at 110, was dissolved (0-001 M) in boiled-out water and titrated potentio-metrically under nitrogen with three equivalents of 0 o 1 N potassium hydroxide added in thirty equal portions. This gave the three ionization ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/177433a0
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  • 6
    Electronic Resource
    Electronic Resource
    The Monosubstituted Pteridines (1954)
    [s.l.] : Nature Publishing Group
    Nature 173 (1954), S. 1046-1047 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] INDEX OP MONOSTJBSTITUTED PTERIDINHS N N N 2 4 6 7 -OH a a b b -OCH, c c b d ~N(CH8)a a a* a c,e b b dd -NHAc a at d -SH f,a a __ d -SCH, d d __ d -CH3 d d __ d -Cl a c b d * The 2-methylamino-analogue is also known (ref. c). t 4-Hydrazinopteridine is also known (ref. d). a ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1731046b0
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  • 7
    Electronic Resource
    Electronic Resource
    Avidity of Terramycin and Aureomycin for Metallic Cations (1953)
    [s.l.] : Nature Publishing Group
    Nature 172 (1953), S. 201-201 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] It is therefore interesting to discover that terramycin and aureomycin also have high affinities for metallic ions. These affinities were put on a quantitative basis by potentiometric titration at 20 (with potassium hydroxide) of the chemically pure monohydrochlorides of these substances (0 001 M) ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/172201a0
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  • 8
    Electronic Resource
    Electronic Resource
    Iso xanthopterin (1953)
    [s.l.] : Nature Publishing Group
    Nature 172 (1953), S. 118-118 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The e at 223 mjx may be subject to a small error from stray light. We wish to thank Dr. E. B. Holiday, of the Medical Research Council Spectrographic Research Unit, London Hospital, and Dr. F. Korte, of the Bio-chemische Abteilung, Chemisches Staatsinstitut of the University of Hamburg, for ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/172118b0
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  • 9
    Electronic Resource
    Electronic Resource
    Destruction of Isoniazid in the Presence of Hæmin (1955)
    [s.l.] : Nature Publishing Group
    Nature 175 (1955), S. 1085-1086 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] When isoniazid (10~2 M) and haemin (10-3 M) were shaken with air at 20 (pH 7-5, phosphate or 'tris' buffer) only two substances were formed : diiso-nicotinoylhydrazine (I) and isonicotinic acid (II). Under these conditions, (I) was not formed from the reaction of isoniazid with (II), as has been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1751085b0
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  • 10
    Electronic Resource
    Electronic Resource
    Chemical Aspects of Selective Toxicity (1958)
    [s.l.] : Nature Publishing Group
    Nature 182 (1958), S. 421-423 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] SELECTIVE toxicity may be defined as the injuring of one kind of cell without injuring some other kind of cell with which the first is in intimate contact1. Thus, in agriculture, it is concerned with ridding crops and seeds of noxious insects and fungi, without causing harm to the higher plants. In ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/182421a0
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