Publication Date:
1980-02-08
Description:
Incubation of rat cerebral cortical slices with the beta-adrenergic agonist isoproterenol causes an increase in alpha 2-adrenergic receptor binding in addition to a decrease in beta-adrenergic receptor binding. The effects are rapid and reversible, show a parallel time course, and are blocked by sotalol, a beta-adrenergic receptor antagonist. The beta-mediated regulation of alpha 2-receptor sensitivity at brain norepinephrine synapses may be a mechanism for the homeostatic control of central noradrenergic activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Maggi, A -- U'Prichard, D C -- Enna, S J -- New York, N.Y. -- Science. 1980 Feb 8;207(4431):645-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6101510" target="_blank"〉PubMed〈/a〉
Keywords:
Adrenergic alpha-Agonists/pharmacology
;
Animals
;
Brain/*drug effects/metabolism
;
Clonidine/analogs & derivatives/metabolism
;
Dihydroalprenolol/metabolism
;
In Vitro Techniques
;
Isoproterenol/antagonists & inhibitors/*pharmacology
;
Male
;
Rats
;
Receptors, Adrenergic/*drug effects
;
Receptors, Adrenergic, alpha/*drug effects
;
Receptors, Adrenergic, beta/*drug effects/metabolism
;
Sotalol/pharmacology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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