Publication Date:
2004-06-05
Description:
Axonal projections from the olfactory epithelium to the olfactory bulb are organized into glomeruli according to the expressed odorant receptor. Using gene-targeted mice, we show that glomerular maturation proceeds along different time courses for two similar receptors and requires sensory input during distinct sensitive periods. During early development, some glomeruli are innervated by axons of neurons that do not express the same receptor. These heterogeneous glomeruli normally disappear with age, but they persist in adults deprived of sensory input by unilateral and permanent naris closure. Persistence may be due, in part, to prolonged survival of olfactory sensory neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zou, Dong-Jing -- Feinstein, Paul -- Rivers, Aimee L -- Mathews, Glennis A -- Kim, Ann -- Greer, Charles A -- Mombaerts, Peter -- Firestein, Stuart -- New York, N.Y. -- Science. 2004 Jun 25;304(5679):1976-9. Epub 2004 Jun 3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biological Sciences, Columbia University, New York, NY 10027, USA. dz98@columbia.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15178749" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Animals, Newborn
;
Axons/*physiology/ultrastructure
;
Cell Death
;
Cell Survival
;
Dendrites/physiology/ultrastructure
;
Gene Targeting
;
Immunohistochemistry
;
Mice
;
Mice, Inbred C57BL
;
Odors
;
Olfactory Bulb/cytology/*growth & development
;
*Olfactory Pathways
;
Olfactory Receptor Neurons/cytology/*physiology
;
Receptors, Odorant/genetics/*metabolism
;
Sensory Deprivation
;
Smell
;
Synapses/ultrastructure
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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