Publication Date:
1979-04-06
Description:
Rat liver microsomes generate methane from dimethyl sulfoxide and ethylene from either methional or 2-keto-4-thiomethylbutyric acid during electron transfer initiated by reduced nicotinamide-adenine dinucleotide phosphate (NADPH). Hydrocarbon gas production is suppressed by hydroxyl radical scavenging agents. Azide, an inhibitor of catalase, augments the production of hydrocarbon gases. These observations constitute chemical evidence for the generation of hydroxyl radicals by microsomes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, G -- Cederbaum, A I -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):66-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432627" target="_blank"〉PubMed〈/a〉
Keywords:
Alcohols/metabolism
;
Animals
;
Catalase/metabolism
;
*Electron Transport
;
Free Radicals
;
Hydrogen Peroxide/metabolism
;
*Hydroxides
;
Male
;
Microsomes, Liver/*metabolism
;
Oxidation-Reduction
;
Rats
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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