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  • 1
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    Unique pathway for anandamide synthesis and liver regeneration [Commentary] (2011)
    National Academy of Sciences
    Details
    Publication Date: 2011-04-20
    Description: The endocannabinoid system (ECS) includes cannabinoid (CB1 and CB2) receptors and their endogenous ligands (i.e., the endocannabinoids anandamide and 2-arachydonylglycerol) as well as proteins involved in endocannabinoids biosynthesis and degradation (1). The ECS is present in the liver and undergoes adaptive changes in response to noxious stimuli. Endocannabinoids as well as CB1 and CB2 receptors (which are, respectively, either faintly or not expressed in normal livers) are up-regulated in experimental liver injury and liver cirrhosis of various etiologies. In vivo, CB1 receptor activation promotes fat accumulation, triggers inflammation in nonalcoholic and alcoholic fatty liver diseases, contributes to the progression of...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
    Published by National Academy of Sciences
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  • 2
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    Redfield's evolving legacy (2014)
    Springer Nature
    Details
    Publication Date: 2014-11-28
    Description: Nature Geoscience 7, 853 (2014). doi:10.1038/ngeo2308 Authors: Nicolas Gruber & Curtis A. Deutsch The ratio of nitrogen to phosphorus in organic matter is close to that in seawater, a relationship maintained through a set of biological feedbacks. The rapid delivery of nutrients from human activities may test the efficacy of these processes.
    Print ISSN: 1752-0894
    Electronic ISSN: 1752-0908
    Topics: Geosciences
    Published by Springer Nature
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  • 3
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    Ecology. Putting the heat on tropical animals (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-06-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Tewksbury, Joshua J -- Huey, Raymond B -- Deutsch, Curtis A -- New York, N.Y. -- Science. 2008 Jun 6;320(5881):1296-7. doi: 10.1126/science.1159328.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biology, University of Washington, Seattle, WA 98195, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18535231" target="_blank"〉PubMed〈/a〉
    Keywords: Acclimatization ; Amphibians/*physiology ; Animals ; *Climate ; *Ecosystem ; Fishes/*physiology ; Geography ; Oceans and Seas ; Population Dynamics ; Reptiles/*physiology ; Seasons ; Seawater ; Temperature ; *Tropical Climate
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Spatial learning in mutant mice (1993)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1993-10-29
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deutsch, J A -- New York, N.Y. -- Science. 1993 Oct 29;262(5134):760-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8235598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Learning Disorders/*genetics ; Memory Disorders/genetics ; Mice ; Mice, Mutant Strains/*psychology ; Psychological Tests ; Spatial Behavior/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    The Chicxulub asteroid impact and mass extinction at the Cretaceous-Paleogene boundary (2010)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2010-03-06
    Description: The Cretaceous-Paleogene boundary approximately 65.5 million years ago marks one of the three largest mass extinctions in the past 500 million years. The extinction event coincided with a large asteroid impact at Chicxulub, Mexico, and occurred within the time of Deccan flood basalt volcanism in India. Here, we synthesize records of the global stratigraphy across this boundary to assess the proposed causes of the mass extinction. Notably, a single ejecta-rich deposit compositionally linked to the Chicxulub impact is globally distributed at the Cretaceous-Paleogene boundary. The temporal match between the ejecta layer and the onset of the extinctions and the agreement of ecological patterns in the fossil record with modeled environmental perturbations (for example, darkness and cooling) lead us to conclude that the Chicxulub impact triggered the mass extinction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schulte, Peter -- Alegret, Laia -- Arenillas, Ignacio -- Arz, Jose A -- Barton, Penny J -- Bown, Paul R -- Bralower, Timothy J -- Christeson, Gail L -- Claeys, Philippe -- Cockell, Charles S -- Collins, Gareth S -- Deutsch, Alexander -- Goldin, Tamara J -- Goto, Kazuhisa -- Grajales-Nishimura, Jose M -- Grieve, Richard A F -- Gulick, Sean P S -- Johnson, Kirk R -- Kiessling, Wolfgang -- Koeberl, Christian -- Kring, David A -- MacLeod, Kenneth G -- Matsui, Takafumi -- Melosh, Jay -- Montanari, Alessandro -- Morgan, Joanna V -- Neal, Clive R -- Nichols, Douglas J -- Norris, Richard D -- Pierazzo, Elisabetta -- Ravizza, Greg -- Rebolledo-Vieyra, Mario -- Reimold, Wolf Uwe -- Robin, Eric -- Salge, Tobias -- Speijer, Robert P -- Sweet, Arthur R -- Urrutia-Fucugauchi, Jaime -- Vajda, Vivi -- Whalen, Michael T -- Willumsen, Pi S -- New York, N.Y. -- Science. 2010 Mar 5;327(5970):1214-8. doi: 10.1126/science.1177265.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉GeoZentrum Nordbayern, Universitat Erlangen-Nurnberg, Schlossgarten 5, D-91054 Erlangen, Germany. schulte@geol.uni-erlangen.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20203042" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Extinction, Biological ; *Fossils ; Geologic Sediments ; Mexico ; *Minor Planets
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    A high-yielding, strictly regioselective prebiotic purine nucleoside formation pathway (2016)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2016-05-14
    Description: The origin of life is believed to have started with prebiotic molecules reacting along unidentified pathways to produce key molecules such as nucleosides. To date, a single prebiotic pathway to purine nucleosides had been proposed. It is considered to be inefficient due to missing regioselectivity and low yields. We report that the condensation of formamidopyrimidines (FaPys) with sugars provides the natural N-9 nucleosides with extreme regioselectivity and in good yields (60%). The FaPys are available from formic acid and aminopyrimidines, which are in turn available from prebiotic molecules that were also detected during the Rosetta comet mission. This nucleoside formation pathway can be fused to sugar-forming reactions to produce pentosides, providing a plausible scenario of how purine nucleosides may have formed under prebiotic conditions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, Sidney -- Thoma, Ines -- Deutsch, Amrei -- Gehrke, Tim -- Mayer, Peter -- Zipse, Hendrik -- Carell, Thomas -- New York, N.Y. -- Science. 2016 May 13;352(6287):833-6. doi: 10.1126/science.aad2808.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig-Maximilians-Universitat Munchen, Department fur Chemie, D-81377 Munich, Germany. ; Ludwig-Maximilians-Universitat Munchen, Department fur Chemie, D-81377 Munich, Germany. thomas.carell@cup.uni-muenchen.de.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/27174989" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 7
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    The stomach signals satiety (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Inflatable pyloric cuffs and stomach tubes were implanted in rats. With the cuff inflated and a valve to limit intragastric pressure to that accompanying normal satiety, they drank only as much when they had been deprived of food for 12 hours as without inflation of the cuff. However, they overdrank with the cuff inflated when they had been water deprived for 12 hours. When 10 ml of milk was withdrawn from the stomach with the cuff inflated, compensatory drinking occurred. Further, compensatory drinking also occurred when milk escaped from the stomach into the duodenum. Satiety signals thus arise from the stomach.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deutsch, J A -- Young, W G -- Kalogeris, T J -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):165-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drinking Behavior/physiology ; Duodenum/physiology ; Food Deprivation ; Male ; Rats ; Satiation/*physiology ; Satiety Response/*physiology ; Stomach/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Vagotomy abolishes cues of satiety produced by gastric distension (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-06-12
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gonzalez, M F -- Deutsch, J A -- New York, N.Y. -- Science. 1981 Jun 12;212(4500):1283-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7233218" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Feeding Behavior ; Kinetics ; Male ; Rats ; *Satiation ; *Satiety Response ; Stomach/*physiology ; *Vagotomy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Reading disability: methodological problems in information-processing analysis (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-19
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deutsch, J A -- New York, N.Y. -- Science. 1978 May 19;200(4343):802.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17743245" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 10
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    Endogenous opiates and fasting (1981)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1981-09-11
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ettenberg, A -- Rogers, J -- Koob, G F -- Bloom, F E -- Deutsch, J A -- New York, N.Y. -- Science. 1981 Sep 11;213(4513):1282.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6267697" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/physiology ; Animals ; Endorphins/*physiology ; *Fasting ; Pituitary Gland/physiology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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