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  • 1
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    Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis (2016)
    Springer Nature
    Details
    Publication Date: 2016-06-23
    Description: Article Late-onset Alzheimer's disease (LOAD) is a complex multi-factorial disorder. Here, the authors perform a data-driven analysis of LOAD progression, including multimodal brain imaging, plasma and CSF biomarkers, and find vascular dysfunction is among the earliest and strongest altered events. Nature Communications doi: 10.1038/ncomms11934 Authors: Y. Iturria-Medina, R. C. Sotero, P. J. Toussaint, J. M. Mateos-Pérez, A. C. Evans
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
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    Structural maturation of neural pathways in children and adolescents: in vivo study (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-03-19
    Description: Structural maturation of fiber tracts in the human brain, including an increase in the diameter and myelination of axons, may play a role in cognitive development during childhood and adolescence. A computational analysis of structural magnetic resonance images obtained in 111 children and adolescents revealed age-related increases in white matter density in fiber tracts constituting putative corticospinal and frontotemporal pathways. The maturation of the corticospinal tract was bilateral, whereas that of the frontotemporal pathway was found predominantly in the left (speech-dominant) hemisphere. These findings provide evidence for a gradual maturation, during late childhood and adolescence, of fiber pathways presumably supporting motor and speech functions.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Paus, T -- Zijdenbos, A -- Worsley, K -- Collins, D L -- Blumenthal, J -- Giedd, J N -- Rapoport, J L -- Evans, A C -- New York, N.Y. -- Science. 1999 Mar 19;283(5409):1908-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec H3A 2B4, Canada. tomas@bic.mni.mcgill.ca〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10082463" target="_blank"〉PubMed〈/a〉
    Keywords: Adolescent ; *Aging ; Axons/physiology/ultrastructure ; Brain/anatomy & histology/*growth & development ; Brain Mapping ; Child ; Child, Preschool ; Female ; Frontal Lobe/anatomy & histology/growth & development ; Humans ; Magnetic Resonance Imaging ; Male ; Motor Skills ; Myelin Sheath/ultrastructure ; Nerve Fibers/ultrastructure ; Neural Conduction ; Neural Pathways/anatomy & histology/*growth & development ; Regression Analysis ; Speech ; Spinal Cord/anatomy & histology ; Synaptic Transmission ; Temporal Lobe/anatomy & histology/growth & development
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Multiple representations of pain in human cerebral cortex (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-03-15
    Description: The representation of pain in the cerebral cortex is less well understood than that of any other sensory system. However, with the use of magnetic resonance imaging and positron emission tomography in humans, it has now been demonstrated that painful heat causes significant activation of the contralateral anterior cingulate, secondary somatosensory, and primary somatosensory cortices. This contrasts with the predominant activation of primary somatosensory cortex caused by vibrotactile stimuli in similar experiments. Furthermore, the unilateral cingulate activation indicates that this forebrain area, thought to regulate emotions, contains an unexpectedly specific representation of pain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Talbot, J D -- Marrett, S -- Evans, A C -- Meyer, E -- Bushnell, M C -- Duncan, G H -- New York, N.Y. -- Science. 1991 Mar 15;251(4999):1355-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratoire de neurophysiologie comportementale, Faculte de medecine dentaire, Universite de Montreal, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2003220" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Animals ; Anxiety/physiopathology ; Brain Mapping ; Cerebral Cortex/*physiology ; Functional Laterality ; Hot Temperature ; Humans ; Magnetic Resonance Imaging ; Male ; Pain/*physiopathology ; Tomography, Emission-Computed
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Lateralization of phonetic and pitch discrimination in speech processing (1992)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1992-05-08
    Description: Cerebral activation was measured with positron emission tomography in ten human volunteers. The primary auditory cortex showed increased activity in response to noise bursts, whereas acoustically matched speech syllables activated secondary auditory cortices bilaterally. Instructions to make judgments about different attributes of the same speech signal resulted in activation of specific lateralized neural systems. Discrimination of phonetic structure led to increased activity in part of Broca's area of the left hemisphere, suggesting a role for articulatory recoding in phonetic perception. Processing changes in pitch produced activation of the right prefrontal cortex, consistent with the importance of right-hemisphere mechanisms in pitch perception.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zatorre, R J -- Evans, A C -- Meyer, E -- Gjedde, A -- New York, N.Y. -- Science. 1992 May 8;256(5058):846-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉McConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Quebec, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1589767" target="_blank"〉PubMed〈/a〉
    Keywords: Acoustic Stimulation ; Auditory Cortex/anatomy & histology/*physiology/radionuclide imaging ; Functional Laterality ; Humans ; Magnetic Resonance Imaging ; *Phonetics ; *Pitch Discrimination ; Reference Values ; Speech ; *Speech Perception ; Tomography, Emission-Computed/methods
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    BigBrain: an ultrahigh-resolution 3D human brain model (2013)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2013-06-22
    Description: Reference brains are indispensable tools in human brain mapping, enabling integration of multimodal data into an anatomically realistic standard space. Available reference brains, however, are restricted to the macroscopic scale and do not provide information on the functionally important microscopic dimension. We created an ultrahigh-resolution three-dimensional (3D) model of a human brain at nearly cellular resolution of 20 micrometers, based on the reconstruction of 7404 histological sections. "BigBrain" is a free, publicly available tool that provides considerable neuroanatomical insight into the human brain, thereby allowing the extraction of microscopic data for modeling and simulation. BigBrain enables testing of hypotheses on optimal path lengths between interconnected cortical regions or on spatial organization of genetic patterning, redefining the traditional neuroanatomy maps such as those of Brodmann and von Economo.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Amunts, Katrin -- Lepage, Claude -- Borgeat, Louis -- Mohlberg, Hartmut -- Dickscheid, Timo -- Rousseau, Marc-Etienne -- Bludau, Sebastian -- Bazin, Pierre-Louis -- Lewis, Lindsay B -- Oros-Peusquens, Ana-Maria -- Shah, Nadim J -- Lippert, Thomas -- Zilles, Karl -- Evans, Alan C -- New York, N.Y. -- Science. 2013 Jun 21;340(6139):1472-5. doi: 10.1126/science.1235381.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Neuroscience and Medicine (INM-1, INM-4), Research Centre Julich, Julich, Germany. k.amunts@fz-juelich.de〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23788795" target="_blank"〉PubMed〈/a〉
    Keywords: Aged ; Brain/*anatomy & histology/*cytology ; *Brain Mapping ; Cerebral Cortex/anatomy & histology/cytology ; Female ; Humans ; Image Processing, Computer-Assisted ; *Imaging, Three-Dimensional ; Magnetic Resonance Imaging ; Microtomy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
    Electronic Resource
    Electronic Resource
    Momentum distributions in fluids determined by neutron compton scattering (1994)
    Springer
    Il nuovo cimento della Società Italiana di Fisica 16 (1994), S. 737-745 
    Details
    ISSN: 0392-6737
    Keywords: Neutron scattering techniques (including small-angle scattering) ; Mixed systems ; liquid helium-3,-4 mixtures ; Conference proceedings
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Summary An introduction is given to the measurement of atomic momentum distribution by scattering of high-energy neutrons. Examples of measurements on liquid hydrogen, solid lithium, quantum fluids Ne and3He-4He mixtures are given. Future prospects for this new technique are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02456719
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Parasitism a Stimulus to Pupation : Alysia manducator in Relation to the Host Lucilia sericata. (1930)
    [s.l.] : Nature Publishing Group
    Nature 125 (1930), S. 598-599 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] CONSIDERABLE diversity of opinion has been expressed regarding the stage in which hibernation of the ‘blow fly’, Lucilia sericata Meigen, takes place. Records are given variously as : (a) Mainly in the pupal, but also in the larval stage.1 (b) Both in pupal and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/125598a0
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  • 8
    Electronic Resource
    Electronic Resource
    Rosette Disease of Groundnuts (1954)
    [s.l.] : Nature Publishing Group
    Nature 173 (1954), S. 1242-1243 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The vector of the disease is Aphis craccwora Koch. In natural bush the vector has been found on about twenty plant species, mostly Leguminosae, at different times of the year. None of these has yet been proved to be a host of the virus1. The principal variety of groundnut grown by the Corporation, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/1731242b0
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  • 9
    Electronic Resource
    Electronic Resource
    Physiological Races of Lucilia sericata , Mg. (1936)
    [s.l.] : Nature Publishing Group
    Nature 137 (1936), S. 33-34 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] RATCLIFFE1 has recently suggested that there may possibly be two physiological races of L. sericata, as the length of the pupal period of this insect at 32°C. in Scotland is 5.4 days while in France at the same temperature it is 8 days. This latter figure is quoted from a paper ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/137033c0
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  • 10
    Electronic Resource
    Electronic Resource
    Evidence for the Existence of Cosmic Ray Particles with Energy ⩾ 5×10 19 eV (1968)
    [s.l.] : Nature Publishing Group
    Nature 219 (1968), S. 343-346 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The analysis of an extremely energetic air shower produced by a primary cosmic ray particle of energy ⩾ 5×1019 eV is described. The flux of particles of this energy is shown to be greater than expected under certain assumptions concerning universal black body radiation and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/219343a0
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