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  • 1
    Publication Date: 2015-08-12
    Description: Article Tumour cells can survive by evading cell death pathways and altering their metabolism to adapt to their local environment. In this study, Iansante et al . show that the anti-apoptotic protein PARP14 maintains low PKM2 activity, leading to enhanced glycolysis, demonstrating a link between suppression of apoptosis and altered metabolism. Nature Communications doi: 10.1038/ncomms8882 Authors: Valeria Iansante, Pui Man Choy, Sze Wai Fung, Ying Liu, Jian-Guo Chai, Julian Dyson, Alberto Del Rio, Clive D’Santos, Roger Williams, Shilpa Chokshi, Robert A Anders, Concetta Bubici, Salvatore Papa
    Electronic ISSN: 2041-1723
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics
    Published by Springer Nature
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  • 2
    Publication Date: 2013-09-18
    Description: Alternative usage of exons provides genomes with plasticity to produce different transcripts from the same gene, modulating the function, localization, and life cycle of gene products. It affects most human genes. For a limited number of cases, alternative functions and tissue-specific roles are known. However, recent high-throughput sequencing studies have...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 3
    Publication Date: 2005-12-20
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mejia, Raymond -- Olivero, Ofelia -- Rivera-Goba, Migdalia -- Anders, Ana -- Caban, Carlos -- Leon-Monzon, Marta -- Marquez, Ernest -- New York, N.Y. -- Science. 2005 Dec 16;310(5755):1767-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/16363026" target="_blank"〉PubMed〈/a〉
    Keywords: Asian Americans/statistics & numerical data ; *Career Mobility ; *Hispanic Americans/statistics & numerical data ; Humans ; National Institutes of Health (U.S.)/*statistics & numerical data ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2016-10-08
    Description: Silicon carbide (SiC) based metal-oxide-semiconductor field-effect transistors (MOSFETs) have great promise in high power and high temperature applications. Unfortunately, effective channel mobilities remain disappointingly low, typically about 30 cm 2 /Vs. A major contributor to the disappointing effective channel mobilities is the presence of substantial densities of interface traps at the SiC/SiO 2 interface. Many investigators have invoked silicon or carbon dangling bonds to be the dominating source of these interface defects, but very little, if any, direct experimental evidence exists to support this assumption in the SiC/SiO 2 system. Cantin et al. [Phys. Rev. Lett. 92 , 1 (2004)] have used conventional electron paramagnetic resonance measurements on porous oxidized SiC structures to measure the g tensor for the SiC/SiO 2 interface carbon dangling bond. These results provide a particularly straightforward means to search for the presence of carbon dangling bonds in fully processed SiC MOSFETs using electrically detected magnetic resonance. Additionally, simple theory provides guidance to search for silicon dangling bond defects. In this study, we utilize K band electrically detected magnetic resonance via spin dependent charge pumping measurements in which almost all of the SiC band gap at the SiC/SiO 2 interface is accessed. Although quite high signal to noise measurements are achieved, we are unable to detect any trace of the carbon dangling bond spectra. However, in very poor quality p-channel devices, we observe a spectrum which could be consistent with silicon dangling bonds. Other defect centers are clearly present and we conclude that these other centers dominate the interface trap density of states.
    Print ISSN: 0003-6951
    Electronic ISSN: 1077-3118
    Topics: Physics
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  • 5
    Publication Date: 2016-11-30
    Description: Programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) checkpoint blockade has led to remarkable and durable objective responses in a number of different tumor types. A better understanding of factors associated with the PD-1/PD-L axis expression is desirable, as it informs their potential role as prognostic and predictive biomarkers and...
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 6
    Publication Date: 1966-01-01
    Print ISSN: 0149-1423
    Electronic ISSN: 1943-2674
    Topics: Geosciences
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  • 7
    Publication Date: 2021-10-14
    Description: Climate has been viewed as a primary control on the rates and patterns of glacial erosion, yet our understanding of the mechanisms by which climate influences glacial erosion is limited. We hypothesize that climate controls the patterns of glacial erosion by altering the basal thermal regime of glaciers. The basal thermal regime is a first-order control on the spatial patterns of glacial erosion. Polythermal glaciers contain both cold-based portions that protect bedrock from erosion and warm-based portions that actively erode bedrock. In this study, we model the impact of various climatic conditions on glacier basal thermal regimes and patterns of glacial erosion in mountainous regions. We couple a sliding-dependent glacial erosion model with the Parallel Ice Sheet Model (PISM) to simulate the evolution of the glacier basal thermal regime and glacial erosion in a synthetic landscape. We find that both basal thermal regimes and glacial erosion patterns are sensitive to climatic conditions, and glacial erosion patterns follow the patterns of the basal thermal regime. Cold temperature leads to limited glacial erosion at high elevations due to cold-based conditions. Increasing precipitation can overcome the impact of cold temperature on the basal thermal regime by accumulating thick ice and lowering the melting point of ice at the base of glaciers. High precipitation rates, therefore, tend to cause warm-based conditions at high elevations, resulting in intensive erosion near the peak of the mountain range. Previous studies often assessed the impact of climate on the spatial patterns of glacial erosion by integrating climatic conditions into the equilibrium line altitudes (ELAs) of glaciers, and glacial erosion is suggested to be maximal around the ELA. However, our results show that different climatic conditions produce glaciers with similar ELAs but different patterns of basal thermal regime and glacial erosion, suggesting that there might not be any direct correlation between ELAs and glacial erosion patterns.
    Language: English
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 8
    Publication Date: 2022-02-15
    Description: In the low-relief post-glacial landscapes of the Central Lowlands of the United States, fluvial networks formed and expanded following deglaciation despite the low slopes and large fraction of the land surface occupied by closed depressions. Low relief topography allows for subtle surface water divides and increases the likelihood that groundwater divides do not coincide with surface water divides. We investigate how groundwater transfer across subtle surface water divides facilitates channel network expansion using a numerical model built on the Landlab platform. Our model simulates surface and subsurface water routing and fluvial erosion. We consider two end-member scenarios for surface water routing, one in which surface water in closed depressions is forced to connect to basin outlets (routing) and one in which surface water in closed depressions is lost to evapotranspiration (no routing). Groundwater is modeled as fully saturated flow within a confined aquifer. Groundwater emerges as surface water where the landscape has eroded to a specified depth. We held the total water flux constant and varied the fraction of water introduced as groundwater versus precipitation. Channel growth is significantly faster in routing cases than no-routing cases given identical groundwater fractions. In both routing and no-routing cases, channel expansion is fastest when ~30% of the total water enters the system as groundwater. Groundwater contributions also produce distinctive morphology including steepened channel profiles below groundwater seeps. Groundwater head gradients evolve with topography and groundwater-fed channels can grow more quickly than channels with larger surface water catchments. We conclude that rates of channel network growth in low-relief post-glacial areas are sensitive to groundwater contributions. More broadly, our findings suggest that landscape evolution models may benefit from more detailed representation of hydrologic processes.
    Language: English
    Type: info:eu-repo/semantics/article
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  • 9
    Publication Date: 2022-05-18
    Description: Unlike well-known plateaus associated with Cenozoic orogens, the Appalachian and Ozark Plateaus of the eastern United States fringe the foreland side of a long inactive and deeply eroded orogen. These foreland intracratonic plateaus (FIPs), which are underlain by sub-horizontal cratonic-platform strata and, in places, foreland-basin strata, now lie 0.5–1.2 km above sea level, notably higher than adjacent fold-thrust belts. An escarpment lies at or near the boundary between the FIPs and the fold-thrust belts. Why did the topographic inversion leading to the development of the FIPs take place? To address this question, we built a numerical model, using Landlab, to simulate how topography evolves as foreland lithosphere flexes upward when post-tectonic erosion causes unloading. In this model, flat-lying cap-rock strata (sandstone and limestone) of the foreland have greater resistance to erosion than do the deformed, tilted, cleaved, and fractured strata of the fold-thrust belt, especially where the fold-thrust belt contains argillaceous facies. We tested the model by characterizing the development of the Ozark Plateau in the foreland of the Ouachita fold-thrust belt. Results demonstrate that regional isostatic uplift due to erosion, given reasonable differences in resistance to erosion between the fold-thrust belt and the foreland, can generate the observed topographic inversion and a distinct escarpment, yielding a plateau. This model may help explain the post-Paleozoic evolution of the Catskill Mountains, the Deep Valleys Province, and the Cumberland Plateau, highlands which border the Appalachian fold-thrust belt.
    Language: English
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Applied physics 20 (1979), S. 257-259 
    ISSN: 1432-0630
    Keywords: 87 ; 42.55
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Selective electronic excitation of single kinds of DNA bases were performed with dye lasers. Different DNA-dye-complexes were used and the selective excitation could be proved by the varying strength of the interaction between the bases and the dye molecules.
    Type of Medium: Electronic Resource
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