Publication Date:
2017-07-13
Description:
Transcription factor Hlx controls a systematic switch from white to brown fat through Prdm16-mediated co-activation Nature Communications, Published online: 12 July 2017; doi:10.1038/s41467-017-00098-2 The transcriptional co-activator Prdm16 regulates browning of white adipose tissue (WAT). Here, the authors show that Prdm16 interacts with the transcription factor Hlx, which is stabilized in response to β3-adrenergic signaling, to increase thermogenic gene expression and mitochondrial biogenesis in subcutaneous WAT.
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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